PMID- 17299518
OWN - NLM
STAT- MEDLINE
DCOM- 20070926
LR  - 20150311
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 32
IP  - 8
DP  - 2007 Aug
TI  - Rewarding effects and reinstatement of MDMA-induced CPP in adolescent mice.
PG  - 1750-9
AB  - Although the rewarding effects of 3,4-methylenedioxy-metamphetamine (MDMA) have 
      been demonstrated in self-administration and conditioned place preference (CPP) 
      procedures, its addictive potential (ie, the vulnerability to relapse, measured 
      by its ability to induce reinstatement of an extinguished response), remains 
      poorly understood. In this study, the effects of MDMA (5, 10, and 20 mg/kg) on 
      the acquisition, extinction and reinstatement of CPP were evaluated in mice, 
      using two different protocols during acquisition of CPP. In the first experiment, 
      animals were trained using a two-session/day schedule (MDMA and saline for 4 
      consecutive days), whereas in the second experiment, they were trained using an 
      alternating day schedule (MDMA and saline each 48 h). After extinction, the 
      ability of drug priming to reinstate CPP was evaluated. In Experiment 1, MDMA did 
      not significantly increase the time spent in the drug-paired compartment during 
      the post-conditioning (Post-C) test, although the preference was evident a week 
      afterwards, lasting between 2 and 21 weeks. No reinstatement was observed after 
      MDMA priming. In Experiment 2, all doses produced CPP in Post-C, which lasted 
      between 1 and 4 weeks. MDMA induces reinstatement at doses up to 4 times lower 
      than those used in conditioning. The analyses of brain monoamines revealed that 
      the daily schedule of treatment induces a non-dose-dependent decrease in dopamine 
      and serotonin (5-HT) in the striatum, whereas the alternating schedule produces a 
      dose-dependent decrease of 5-HT in the cortex. These results demonstrate that 
      MDMA produces long-lasting rewarding effects and reinstatement after extinction, 
      suggesting the susceptibility of this drug to induce addiction.
FAU - Daza-Losada, Manuel
AU  - Daza-Losada M
AD  - Facultad de Psicologia, Departamento de Psicobiologia, Unidad de Investigacion 
      Psicobiologia de las Drogodependencias, Universitat de Valencia, Valencia, Spain.
FAU - Ribeiro Do Couto, Bruno
AU  - Ribeiro Do Couto B
FAU - Manzanedo, Carmen
AU  - Manzanedo C
FAU - Aguilar, Maria A
AU  - Aguilar MA
FAU - Rodriguez-Arias, Marta
AU  - Rodriguez-Arias M
FAU - Minarro, Jose
AU  - Minarro J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070214
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Biogenic Amines)
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/drug effects
MH  - Biogenic Amines/metabolism
MH  - Brain Chemistry/drug effects
MH  - Conditioning, Operant/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Extinction, Psychological/drug effects
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Reinforcement Schedule
MH  - *Reward
EDAT- 2007/02/15 09:00
MHDA- 2007/09/27 09:00
CRDT- 2007/02/15 09:00
PHST- 2007/02/15 09:00 [pubmed]
PHST- 2007/09/27 09:00 [medline]
PHST- 2007/02/15 09:00 [entrez]
AID - 1301309 [pii]
AID - 10.1038/sj.npp.1301309 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2007 Aug;32(8):1750-9. doi: 10.1038/sj.npp.1301309. Epub 
      2007 Feb 14.