PMID- 17299707
OWN - NLM
STAT- MEDLINE
DCOM- 20070504
LR  - 20220311
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 195
IP  - 6
DP  - 2007 Mar 15
TI  - Etiology of severe sensorineural hearing loss in children: independent impact of 
      congenital cytomegalovirus infection and GJB2 mutations.
PG  - 782-8
AB  - BACKGROUND: Sensorineural hearing loss (SNHL) is the most common congenital 
      disease. Longitudinal studies of infants with congenital cytomegalovirus (CMV) 
      infection have demonstrated an association between CMV and SNHL. However, because 
      of the lack of suitable neonatally collected specimens, the proportion of 
      CMV-associated SNHL has not been defined, nor has the relationship between CMV 
      and the major genetic causes of SNHL, such as mutations in the GJB2 gene. 
      METHODS: Sixty-seven children with severe SNHL were analyzed for CMV and human 
      herpesvirus 6 (HHV-6) infections and for GJB2 mutations. DNA specimens were 
      prepared from dried umbilical cords, which are available for everyone born in 
      Japan. Four children with typical symptomatic infection at birth served as 
      positive control subjects. RESULTS: Congenital CMV infection and GJB2 mutations 
      were identified in 15% and 24% of the patients, respectively. HHV-6 was not 
      detected. All children with CMV-associated cases developed SNHL before they were 
      2 years old. Most children with CMV-associated SNHL had no obvious clinical 
      abnormality at birth, and their viral loads were lower than those of symptomatic 
      children. CONCLUSIONS: Congenital CMV infection is an important cause of severe 
      SNHL, and it has an incidence comparable to that of GJB2-associated SNHL.
FAU - Ogawa, Hiroshi
AU  - Ogawa H
AD  - National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
FAU - Suzutani, Tatsuo
AU  - Suzutani T
FAU - Baba, Yohko
AU  - Baba Y
FAU - Koyano, Shin
AU  - Koyano S
FAU - Nozawa, Naoki
AU  - Nozawa N
FAU - Ishibashi, Kei
AU  - Ishibashi K
FAU - Fujieda, Kenji
AU  - Fujieda K
FAU - Inoue, Naoki
AU  - Inoue N
FAU - Omori, Koichi
AU  - Omori K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070206
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Connexins)
RN  - 0 (DNA Primers)
RN  - 0 (GJB2 protein, human)
RN  - 127120-53-0 (Connexin 26)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - J Infect Dis. 2007 Mar 15;195(6):767-9. PMID: 17299704
MH  - Base Sequence
MH  - Connexin 26
MH  - Connexins/*genetics
MH  - Cytomegalovirus/*isolation & purification
MH  - Cytomegalovirus Infections/*epidemiology
MH  - DNA/blood/genetics/isolation & purification
MH  - DNA Primers
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Genetic Predisposition to Disease
MH  - Hearing Loss, Sensorineural/*etiology/genetics
MH  - Hearing Tests
MH  - Herpesvirus 6, Human/isolation & purification
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - *Mutation
EDAT- 2007/02/15 09:00
MHDA- 2007/05/05 09:00
CRDT- 2007/02/15 09:00
PHST- 2006/07/02 00:00 [received]
PHST- 2006/09/12 00:00 [accepted]
PHST- 2007/02/15 09:00 [pubmed]
PHST- 2007/05/05 09:00 [medline]
PHST- 2007/02/15 09:00 [entrez]
AID - JID37064 [pii]
AID - 10.1086/511981 [doi]
PST - ppublish
SO  - J Infect Dis. 2007 Mar 15;195(6):782-8. doi: 10.1086/511981. Epub 2007 Feb 6.