PMID- 17300675
OWN - NLM
STAT- MEDLINE
DCOM- 20070619
LR  - 20220309
IS  - 1320-5463 (Print)
IS  - 1320-5463 (Linking)
VI  - 57
IP  - 2
DP  - 2007 Feb
TI  - CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma of ocular adnexal 
      origin: usefulness of fluorescence in situ hybridization for distinction between 
      mantle cell lymphoma and MALT lymphoma.
PG  - 101-7
AB  - Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue 
      type (MALT lymphoma) usually lacks CD5 expression. Herein is described two cases 
      of CD5-positive MALT lymphoma of ocular adnexal origin. The differential 
      diagnosis between CD5-positive MALT lymphoma and mantle cell lymphoma (MCL), 
      notably cyclin D1-negative MCL, was difficult because both cases consisted 
      histologically of small to medium-sized cells with diffuse or vaguely nodular 
      growth pattern, and the neoplastic cells were positive for CD5 and negative for 
      cyclin D1. Somatic mutation analysis of the immunoglobulin heavy chain variable 
      region (VH) gene in case 1 found a relatively higher mutation frequency (5.0%), 
      which was not definitive to rule out MCL. Interphase fluorescence in situ 
      hybridization (FISH) on paraffin-embedded section using IgH/cyclin D1 (CCND1) 
      probe showed that in both cases there was no molecular evidence of t(11;14), 
      finally leading to the diagnosis of CD5-positive MALT lymphoma. Although the 
      present two patients had no recurrence over 34 months after initial diagnosis, 
      careful observation is needed because the clinicopathological significance of 
      MALT lymphoma with this rare phenotype remains obscure.
FAU - Tasaki, Kazuhiro
AU  - Tasaki K
AD  - Department of Pathology, Fukushima Medical University, School of Medicine, 
      Fukushima, Japan. tasakika@fmu.ac.jp
FAU - Shichishima, Akiko
AU  - Shichishima A
FAU - Furuta, Minoru
AU  - Furuta M
FAU - Yoshida, Sayaka
AU  - Yoshida S
FAU - Nakamura, Naoya
AU  - Nakamura N
FAU - Abe, Masafumi
AU  - Abe M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (CD5 Antigens)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Aged
MH  - CD5 Antigens/analysis/genetics/*metabolism
MH  - Cyclin D1/genetics/metabolism
MH  - DNA, Neoplasm/genetics
MH  - Diagnosis, Differential
MH  - Eye Neoplasms/*diagnosis/genetics/metabolism
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics/metabolism
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*diagnosis/genetics/metabolism
MH  - Lymphoma, Mantle-Cell/*diagnosis/genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Adnexal and Skin Appendage/*diagnosis/genetics/metabolism
EDAT- 2007/02/16 09:00
MHDA- 2007/06/20 09:00
CRDT- 2007/02/16 09:00
PHST- 2007/02/16 09:00 [pubmed]
PHST- 2007/06/20 09:00 [medline]
PHST- 2007/02/16 09:00 [entrez]
AID - PIN2063 [pii]
AID - 10.1111/j.1440-1827.2006.02063.x [doi]
PST - ppublish
SO  - Pathol Int. 2007 Feb;57(2):101-7. doi: 10.1111/j.1440-1827.2006.02063.x.