PMID- 17300987
OWN - NLM
STAT- MEDLINE
DCOM- 20070920
LR  - 20161124
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 9
IP  - 5
DP  - 2007 May
TI  - Plasma B-type natriuretic peptide concentration in beta-thalassaemia patients.
PG  - 537-41
AB  - BACKGROUND: Plasma B-type natriuretic peptide (BNP) concentration has significant 
      diagnostic accuracy and prognostic value in various forms of heart disease. 
      Whether BNP is also useful in the evaluation and management of thalassaemia heart 
      disease remains to be determined. METHODS AND RESULTS: Eighty three thalassaemia 
      major patients; 8 with acutely decompensated heart failure (New York Heart 
      Association [NYHA] class III or IV, group A), 25 with NYHA class II symptoms and 
      impaired systolic left ventricular function (ejection fraction<55% or fractional 
      shortening<30%, group B) and 50 with normal systolic function (group C), as well 
      as 50 healthy controls, were studied. Assessment included history, physical 
      examination, Doppler echocardiography and plasma BNP determination. Mean BNP 
      levels were 431+/-219 pg/mL (range, 283-890 pg/mL) in group A, 158+/-31 pg/mL in 
      group B, 176+/-54 pg/mL in group C and 43+/-24 pg/mL in controls. BNP levels were 
      significantly higher in group A (p<0.001), but did not differ between groups B 
      and C. Moreover, BNP was not correlated with left ventricular end-diastolic 
      diameter, left ventricular mass, right ventricular diameter index, Doppler 
      diastolic indexes (except in group C), the mean 2-year serum ferritin 
      concentration or the peak serum ferritin concentration in any of the three 
      patient groups. CONCLUSION: A potential deficiency of BNP-related neurohormonal 
      mechanisms may impair its clinical usefulness in thalassaemia major.
FAU - Aessopos, Athanasios
AU  - Aessopos A
AD  - Cardiac Outpatient Clinic for Hemoglobinopathies, First Department of Internal 
      Medicine, University of Athens Medical School, Laiko General Hospital, Greece.
FAU - Farmakis, Dimitrios
AU  - Farmakis D
FAU - Polonifi, Aikaterini
AU  - Polonifi A
FAU - Tsironi, Maria
AU  - Tsironi M
FAU - Fragodimitri, Christina
AU  - Fragodimitri C
FAU - Hatziliami, Antonia
AU  - Hatziliami A
FAU - Karagiorga, Markisia
AU  - Karagiorga M
FAU - Diamanti-Kandarakis, Evanthia
AU  - Diamanti-Kandarakis E
LA  - eng
PT  - Journal Article
DEP - 20070214
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Echocardiography, Doppler
MH  - Female
MH  - Ferritins/blood
MH  - Greece
MH  - Heart Failure/blood/diagnostic imaging/etiology/physiopathology
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Research Design
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/blood/diagnostic imaging/etiology/physiopathology
MH  - beta-Thalassemia/*blood/complications
EDAT- 2007/02/16 09:00
MHDA- 2007/09/21 09:00
CRDT- 2007/02/16 09:00
PHST- 2006/05/25 00:00 [received]
PHST- 2006/09/09 00:00 [revised]
PHST- 2006/12/04 00:00 [accepted]
PHST- 2007/02/16 09:00 [pubmed]
PHST- 2007/09/21 09:00 [medline]
PHST- 2007/02/16 09:00 [entrez]
AID - S1388-9842(06)00397-7 [pii]
AID - 10.1016/j.ejheart.2006.12.004 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2007 May;9(5):537-41. doi: 10.1016/j.ejheart.2006.12.004. Epub 
      2007 Feb 14.