PMID- 17301401
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220408
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 3
IP  - 3
DP  - 2004 Sep
TI  - Interferon-gamma gene polymorphism in Iranian patients with multiple sclerosis.
PG  - 115-9
AB  - Interferon- gamma (IFN- gamma) is an important immune regulator and inflammatory 
      cytokine which is implicated in the pathogenesis of multiple sclerosis (MS). A 
      single nucleotide polymorphism, T to A, at position +874 in the first intron has 
      previously been shown. This polymorphism is associated with IFN- gamma production 
      level. To study the effect of this polymorphism on susceptibility to multiple 
      sclerosis, we screened genomic DNA samples from clinically definite MS patients 
      and their unaffected first-degree relatives as controls, using sequence-specific 
      primers (PCR-SSP). The results indicated that MS patients showed a lower TT 
      (21.2% vs. 30.3%) and higher AA (21.2% vs. 12.1%) genotypes compared to controls, 
      although there were statistically no differences in the IFN- gamma genotype 
      distribution between these two groups. Thus, our data indicate that there is no 
      association between IFN- gamma +874 polymorphism and MS susceptibility or 
      severity of the disease.
FAU - Izad, Maryam
AU  - Izad M
AD  - Department of Immunology, Faculty of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran. izadm@sina.tums.ac.ir.
FAU - Vodjgani, Mohammad
AU  - Vodjgani M
FAU - Nicknam, Mohammad Hossein
AU  - Nicknam MH
FAU - Lotfi, Jamshid
AU  - Lotfi J
FAU - Fathi, Davood
AU  - Fathi D
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
EDAT- 2007/02/16 09:00
MHDA- 2007/02/16 09:01
CRDT- 2007/02/16 09:00
PHST- 2007/02/16 09:00 [pubmed]
PHST- 2007/02/16 09:01 [medline]
PHST- 2007/02/16 09:00 [entrez]
AID - 0303115119 [pii]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2004 Sep;3(3):115-9.