PMID- 17301632
OWN - NLM
STAT- MEDLINE
DCOM- 20070517
LR  - 20070215
IS  - 1741-8267 (Print)
IS  - 1741-8267 (Linking)
VI  - 14
IP  - 1
DP  - 2007 Feb
TI  - Physical training in patients with chronic heart failure of ischemic origin: 
      effect on exercise capacity and left ventricular remodeling.
PG  - 85-91
AB  - BACKGROUND: Physical training is a well-known complementary treatment for chronic 
      heart failure (CHF); however, many aspects require further studies. One of them 
      is the impact on remodeling of the left ventricle (LV). The purpose of this study 
      was to evaluate the effect of 6 months of training on LV, exercise capacity and 
      safety issues in patients with ischemic CHF. METHODS: Fifty patients (mean age 
      60.1+/-9.2 years) with ischemic CHF, New York Heart Association (NYHA) 
      classification class II and III and left ventricular ejection fraction (LVEF) 
      <or=35% were randomized into groups: undergoing 6-month training (25 patients) 
      and not trained (25 patients). In both groups at baseline and at 6 months a 
      cardiopulmonary exercise test and magnetic resonance imaging (MRI) with 
      evaluation of LV were performed. Training was limited by the achievement of 80% 
      of the predicted heart rate at VO2peak achieved at the baseline cardiopulmonary 
      exercise test. RESULTS: All patients completed the 6-month observation. No 
      serious adverse events were found in either group. Exercise capacity improved 
      only in the trained group (VO2peak increased by 31%). At 6 months in the trained 
      group there was a tendency towards an improvement in some LV parameters: ejection 
      fraction, end-diastolic volume and wall motion score index (WMSI), whereas an 
      opposite trend was seen in the controls (P<0.05, P<0.05 and P<0.01 for comparison 
      of LVEFs, end-diastolic volumes and WMSIs, respectively). CONCLUSIONS: Six-month 
      training in ischemic CHF patients is a safe modality. Training improves exercise 
      capacity. There was no negative impact on LV morphology, and a trend towards 
      improvement of functional parameters on MRI may suggest an anti-remodeling effect 
      of training in patients with ischemic CHF.
FAU - Klecha, Artur
AU  - Klecha A
AD  - I Cardiac Department, Jagiellonian University Medical College, Krakow, Poland. 
      arturklecha@poczta.onet.pl
FAU - Kawecka-Jaszcz, Kalina
AU  - Kawecka-Jaszcz K
FAU - Bacior, Bogumila
AU  - Bacior B
FAU - Kubinyi, Aleksandra
AU  - Kubinyi A
FAU - Pasowicz, Mieczyslaw
AU  - Pasowicz M
FAU - Klimeczek, Piotr
AU  - Klimeczek P
FAU - Banys, Robert
AU  - Banys R
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Cardiovasc Prev Rehabil
JT  - European journal of cardiovascular prevention and rehabilitation : official 
      journal of the European Society of Cardiology, Working Groups on Epidemiology & 
      Prevention and Cardiac Rehabilitation and Exercise Physiology
JID - 101192000
SB  - IM
MH  - Aged
MH  - Cardiac Output, Low/*complications/*therapy
MH  - Chronic Disease
MH  - Exercise Test
MH  - Exercise Therapy
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*complications/*therapy
MH  - Quality of Life
MH  - Treatment Outcome
MH  - Ventricular Function, Left/*physiology
MH  - *Ventricular Remodeling
EDAT- 2007/02/16 09:00
MHDA- 2007/05/18 09:00
CRDT- 2007/02/16 09:00
PHST- 2007/02/16 09:00 [pubmed]
PHST- 2007/05/18 09:00 [medline]
PHST- 2007/02/16 09:00 [entrez]
AID - 00149831-200702000-00013 [pii]
AID - 10.1097/HJR.0b013e3280114f12 [doi]
PST - ppublish
SO  - Eur J Cardiovasc Prev Rehabil. 2007 Feb;14(1):85-91. doi: 
      10.1097/HJR.0b013e3280114f12.