PMID- 17301827
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20111117
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 8
IP  - 3
DP  - 2007 Apr
TI  - Different HLA class II associations in ulcerative colitis patients with and 
      without primary sclerosing cholangitis.
PG  - 275-8
AB  - Approximately 80% of patients with primary sclerosing cholangitis (PSC) of 
      Northern European origin have inflammatory bowel disease (IBD), the majority 
      ulcerative colitis (UC). An inherent problem in interpreting positive findings in 
      genetic association studies of PSC is thus to distinguish between factors 
      associated with hepatobiliary versus intestinal pathology. We aimed to clarify to 
      what extent human leukocyte antigen (HLA) class II associations in UC patients 
      with and without PSC differ. High-resolution DRB1 and DQB1 typing was performed 
      in 365 Scandinavian PSC patients, an independent cohort of 330 Norwegian UC 
      patients and 368 healthy controls. HLA associations found in PSC were mostly 
      distinct from those seen in UC, and no significant differences were noted between 
      PSC patients with concurrent UC and PSC patients without IBD. This suggests 
      different HLA associated genetic susceptibility to PSC and UC, and supports 
      notions that UC in PSC may represent a distinct UC phenotype.
FAU - Karlsen, T H
AU  - Karlsen TH
AD  - Medical Department, Rikshospitalet-Radiumhospitalet Medical Center, University of 
      Oslo, Oslo, Norway. t.h.karlsen@klinmed.uio.no
FAU - Boberg, K M
AU  - Boberg KM
FAU - Vatn, M
AU  - Vatn M
FAU - Bergquist, A
AU  - Bergquist A
FAU - Hampe, J
AU  - Hampe J
FAU - Schrumpf, E
AU  - Schrumpf E
FAU - Thorsby, E
AU  - Thorsby E
FAU - Schreiber, S
AU  - Schreiber S
FAU - Lie, B A
AU  - Lie BA
CN  - IBSEN Study Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20070215
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cholangitis, Sclerosing/*complications/genetics/*immunology
MH  - Colitis, Ulcerative/*complications/genetics/*immunology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - *HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - *HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Norway
MH  - Sweden
EDAT- 2007/02/16 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/02/16 09:00
PHST- 2007/02/16 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/02/16 09:00 [entrez]
AID - 6364377 [pii]
AID - 10.1038/sj.gene.6364377 [doi]
PST - ppublish
SO  - Genes Immun. 2007 Apr;8(3):275-8. doi: 10.1038/sj.gene.6364377. Epub 2007 Feb 15.