PMID- 1730249
OWN - NLM
STAT- MEDLINE
DCOM- 19920218
LR  - 20041117
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 22
IP  - 1
DP  - 1992 Jan
TI  - Acute human vs. mouse graft vs. host disease in normal and immunodeficient mice.
PG  - 197-206
AB  - Recent reports of persistent engraftment of human lymphocytes and myeloid cells 
      in hereditary immunodeficient severe combined immunodeficient mice (SCID) and 
      beige athymic nude X-linked immunodeficiency (Bg/Nu/XID) mice have raised the 
      question of why attempts to graft human cells into artificially immunosuppressed 
      normal mice have failed so far. In the present study we provide evidence that 
      this difference is due to the absence of natural antibodies in the mutant mice. 
      We demonstrate that human PBL can be grafted in normal mice immunosuppressed by 
      heavy doses of total body irradiation, provided the transplant is performed when 
      the recipients lack natural antibodies in their serum, e.g. as in newborn normal 
      mice, in mice treated with anti-mouse IgM antibody from birth, and in 3-week-old 
      B cell-deficient CBA/N mice. In all cases, large numbers of human PBL were 
      required. Under these conditions an acute and fatal graft vs. host disease (GVHD) 
      developed in the recipients, regardless of whether these were artificially 
      immunosuppressed or hereditary immunodeficient. The clinical manifestations and 
      the histopathology of this xenogeneic acute GVHD are quite different from those 
      of allogeneic GVHD. The former is primarily confined to the hematolymphoid 
      tissues and locations close to accumulations of proliferating lymphoblasts, such 
      as the peritoneal cavity in case of i.p. transplantation. The discordant 
      xenogeneic GVHD is induced by human T lymphocytes and can be abrogated by 
      treatment with anti-human T cell serum.
FAU - Huppes, W
AU  - Huppes W
AD  - Institute of Radiobiology, Erasmus University, Rotterdam, The Netherlands.
FAU - De Geus, B
AU  - De Geus B
FAU - Zurcher, C
AU  - Zurcher C
FAU - Van Bekkum, D W
AU  - Van Bekkum DW
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antibodies)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Antibodies/analysis
MH  - Bone Marrow Transplantation
MH  - Chimera
MH  - Graft vs Host Disease/*etiology/pathology
MH  - Humans
MH  - *Immune Tolerance
MH  - Lymphocyte Activation
MH  - *Lymphocyte Transfusion
MH  - Mice
MH  - Mice, Inbred Strains
MH  - *Transplantation, Heterologous
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1002/eji.1830220129 [doi]
PST - ppublish
SO  - Eur J Immunol. 1992 Jan;22(1):197-206. doi: 10.1002/eji.1830220129.