PMID- 17302711
OWN - NLM
STAT- MEDLINE
DCOM- 20070612
LR  - 20080118
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 30 Suppl 1
DP  - 2007 Jan
TI  - Upgrading from single chamber right ventricular to biventricular pacing in 
      permanently paced patients with worsening heart failure: The RD-CHF Study.
PG  - S23-30
AB  - BACKGROUND: Biventricular (BiV) stimulation lowers morbidity and mortality in 
      patients with drug-refractory congestive heart failure (CHF), depressed left 
      ventricular (LV) function, and ventricular dyssynchrony in absence of indication 
      for permanent cardiac pacing. This pilot, single-blind, randomized, cross-over 
      study examined the safety and efficacy of upgrading conventional pacing systems 
      to BiV stimulation in patients with advanced CHF. METHODS: We included 56 
      patients in New York Heart Association (NYHA) functional classes III or IV 
      despite optimal drug treatment and ventricular dyssynchrony (interventriclar 
      delay > 40 ms or LV preejection delay > 140 ms) in need of pacemaker replacement. 
      We compared the patients' functional status, arrhythmias, and standard 
      echocardiographic measurements during 3 months of conventional, single right 
      ventricular (RV) versus 3 months of BiV stimulation. RESULTS: There were 44 
      patients in the cross-over phase. QRS duration was shortened by 23% and LV 
      preejection delay by 16% with BiV stimulation. NYHA functional class, 6-minute 
      hall walk and quality of life score were significantly improved with BiV 
      stimulation compared with single RV pacing by 18%, 29%, and 19%, respectively. No 
      significant difference was observed in the ventricular arrhythmia burden or LV 
      reverse remodeling between the 2 periods. CONCLUSIONS: This pilot study showed 
      that upgrading from RV pacing to BiV pacing significantly improves symptoms and 
      exercise tolerance in chronically paced patients with advanced CHF and mechanical 
      dyssynchrony.
FAU - Leclercq, Christophe
AU  - Leclercq C
AD  - Centre Cardio-Pneumologique, CHU, Rennes, France. 
      christophe.leclercq@chu-rennes.fr
FAU - Cazeau, Serge
AU  - Cazeau S
FAU - Lellouche, David
AU  - Lellouche D
FAU - Fossati, Fabien
AU  - Fossati F
FAU - Anselme, Frederic
AU  - Anselme F
FAU - Davy, Jean-Marc
AU  - Davy JM
FAU - Sadoul, Nicolas
AU  - Sadoul N
FAU - Klug, Didier
AU  - Klug D
FAU - Mollo, Luca
AU  - Mollo L
FAU - Daubert, Jean-Claude
AU  - Daubert JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
EIN - Pacing Clin Electrophysiol. 2007 Nov;30(11):1424
MH  - Aged
MH  - Arrhythmias, Cardiac/etiology/prevention & control
MH  - Cardiac Pacing, Artificial/*methods
MH  - Cross-Over Studies
MH  - Disease Progression
MH  - Exercise Tolerance
MH  - Female
MH  - Heart Failure/complications/*therapy
MH  - Heart Ventricles
MH  - Humans
MH  - Male
MH  - *Pacemaker, Artificial
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left
EDAT- 2007/02/17 09:00
MHDA- 2008/01/19 09:00
CRDT- 2007/02/17 09:00
PHST- 2007/02/17 09:00 [pubmed]
PHST- 2008/01/19 09:00 [medline]
PHST- 2007/02/17 09:00 [entrez]
AID - PACE598 [pii]
AID - 10.1111/j.1540-8159.2007.00598.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2007 Jan;30 Suppl 1:S23-30. doi: 
      10.1111/j.1540-8159.2007.00598.x.