PMID- 17302716
OWN - NLM
STAT- MEDLINE
DCOM- 20070612
LR  - 20220408
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 30 Suppl 1
DP  - 2007 Jan
TI  - Long-term performance of coronary sinus leads used for cardiac resynchronization 
      therapy.
PG  - S47-9
AB  - BACKGROUND: Little is known regarding the long-term performance of coronary sinus 
      (CS) leads, which have an effect on the longevity of cardiac resynchronization 
      therapy (CRT) systems. METHODS: This study included 109 patients (79 men) whose 
      mean age was 68 +/- 9 years, New York Heart Association (NYHA) functional class 
      3.2 +/- 0.5, and left ventricular ejection fraction 25.6 +/- 6.6%, and who 
      underwent CRT (n = 45) or CRT-D (n = 64) systems implants for management of 
      idiopathic (53%), ischemic (40%), or miscellaneous (7%) dilated cardiomyopathy. 
      Unipolar (n = 57) or bipolar (n = 52) leads were placed into the CS venous 
      system. RESULTS: At implant, no significant difference was observed between 
      unipolar and bipolar leads with respect to mean sensing performance (14 +/- 6 mV 
      vs 14 +/- 8 mV, P = 0.97), pacing impedance (875 +/- 234 ohms vs 943 +/- 331 
      ohms, P = 0.24), and stimulation energy threshold (2 +/- 3.2 muJ vs 1.13 +/- 1.5 
      muJ, P = 0.08). At a median follow-up of 33 months, a significant decrease in 
      stimulation impedance and increase in stimulation energy threshold was observed 
      with unipolar (689 +/- 122 vs 875 +/- 234 ohms, P < 0.01, and 8.34 +/- 10.4 muJ 
      vs 2 +/- 3.2 muJ, P < 0.001, respectively) as well as with bipolar (735 +/- 268 
      ohms vs 943 +/- 331 ohms, P < 0.01, and 4.81 +/- 9.92 vs 1.13 +/- 1.5 muJ, P = 
      0.02, respectively) leads. No significant difference in sensing performance was 
      observed with either type of lead (10 +/- 5 mV vs 14 +/- 6 mV and 10 +/- 6 mV vs 
      14 +/- 8 mV, respectively). At long-term follow-up, no significant difference 
      among any sensing or stimulation parameter was observed between unipolar and 
      bipolar leads. CONCLUSIONS: At long-term follow-up, a significant increase in the 
      energy required for stimulation was observed, whereas sensing performance 
      remained unchanged. The increase in energy capture threshold was less marked with 
      bipolar than with unipolar leads.
FAU - Iuliano, Assunta
AU  - Iuliano A
AD  - Casa di Cura San Michele, Maddaloni (CE), Italy.
FAU - Shopova, Gergana
AU  - Shopova G
FAU - De Simone, Antonio
AU  - De Simone A
FAU - Solimene, Francesco
AU  - Solimene F
FAU - Turco, Pietro
AU  - Turco P
FAU - Marrazzo, Natale
AU  - Marrazzo N
FAU - La Rocca, Vincenzo
AU  - La Rocca V
FAU - Ciardiello, Carmine
AU  - Ciardiello C
FAU - Agrusta, Marco
AU  - Agrusta M
FAU - Stabile, Giuseppe
AU  - Stabile G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
EIN - Pacing Clin Electrophysiol. 2007 Nov;30(11):1425
MH  - Aged
MH  - Cardiac Pacing, Artificial/*methods
MH  - Coronary Sinus
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial/*standards
MH  - Treatment Outcome
EDAT- 2007/02/17 09:00
MHDA- 2008/01/19 09:00
CRDT- 2007/02/17 09:00
PHST- 2007/02/17 09:00 [pubmed]
PHST- 2008/01/19 09:00 [medline]
PHST- 2007/02/17 09:00 [entrez]
AID - PACE603 [pii]
AID - 10.1111/j.1540-8159.2007.00603.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2007 Jan;30 Suppl 1:S47-9. doi: 
      10.1111/j.1540-8159.2007.00603.x.