PMID- 17302720
OWN - NLM
STAT- MEDLINE
DCOM- 20070612
LR  - 20161124
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 30 Suppl 1
DP  - 2007 Jan
TI  - Acute left ventricular dyssynchrony improvement predicts long-term benefit from 
      cardiac resynchronization therapy.
PG  - S62-5
AB  - STUDY OBJECTIVE: To evaluate the relationship between acute response to cardiac 
      resynchronization therapy (CRT) and long-term clinical outcome in patients with 
      drug refractory heart failure. METHODS AND RESULTS: In 28 patients undergoing CRT 
      implant, left ventricular (LV) dyssynchrony was evaluated by tissue Doppler 
      imaging (TDI)-derived longitudinal strain by mean of septum-lateral basal 
      asynchrony index (S-Li) and basal delayed longitudinal contraction (DLC). TDI 
      measurements were made before, and 30 minutes and 1 year after implant. Baseline 
      and 1-year follow-up New York Heart Association (NYHA) functional class, 6-minute 
      walking test (6-MWT) distance, and quality of life (QoL) score were measured. 
      Responders (n = 22) were defined by a >/= 1 decrease in NYHA functional class and 
      6-MWT >/= 25% at 1 year. At baseline, no differences were observed between 
      responders and nonresponders in clinical and echocardiographic measurements. LV 
      dyssynchrony acutely recovered only in responders 30 minutes after implantation, 
      with a significant reduction in S-Li and DLC. Moreover, the percent decreases in 
      S-Li and DLC were highly correlated with those observed in NYHA class (r = 0.70, 
      and r = 0.81, respectively, P < 0.001), 6-MWT (r = 0.59, and r = 0.57, 
      respectively, P < 0.001 and P < 0.01), and QoL score (r = 0.71, and r = 0.83, 
      respectively, p < 0.001) at 1-year follow-up. CONCLUSIONS: Acute recovery of LV 
      intraventricular dyssynchrony is a major discriminator between responders and 
      nonresponders to CRT, which strongly correlates with a favorable long-term 
      clinical outcome.
FAU - Capasso, Fabio
AU  - Capasso F
AD  - Laboratorio di Elettrofisiologia, Casa di Cura San Michele Maddaloni (CE), Italy.
FAU - Giunta, Anna
AU  - Giunta A
FAU - De Simone, Antonio
AU  - De Simone A
FAU - Turco, Pietro
AU  - Turco P
FAU - La Rocca, Vincenzo
AU  - La Rocca V
FAU - Grimaldi, M Gabriella
AU  - Grimaldi MG
FAU - Iuliano, Assunta
AU  - Iuliano A
FAU - Stabile, Giuseppe
AU  - Stabile G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
EIN - Pacing Clin Electrophysiol. 2007 Nov;30(11):1424
MH  - Acute Disease
MH  - Aged
MH  - *Cardiac Pacing, Artificial
MH  - Echocardiography, Doppler
MH  - Female
MH  - Heart Failure/complications/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/diagnostic imaging/etiology/*physiopathology
EDAT- 2007/02/17 09:00
MHDA- 2008/01/19 09:00
CRDT- 2007/02/17 09:00
PHST- 2007/02/17 09:00 [pubmed]
PHST- 2008/01/19 09:00 [medline]
PHST- 2007/02/17 09:00 [entrez]
AID - PACE607 [pii]
AID - 10.1111/j.1540-8159.2007.00607.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2007 Jan;30 Suppl 1:S62-5. doi: 
      10.1111/j.1540-8159.2007.00607.x.