PMID- 17304084
OWN - NLM
STAT- MEDLINE
DCOM- 20070412
LR  - 20220317
IS  - 0025-7079 (Print)
IS  - 0025-7079 (Linking)
VI  - 45
IP  - 3
DP  - 2007 Mar
TI  - Psychometric comparison of the standard EQ-5D to a 5 level version in cancer 
      patients.
PG  - 259-63
AB  - OBJECTIVE: The objectives of this study were: 1) to determine whether expanding 
      the number of levels (ie, response categories) on the standard 3 level EQ-5D 
      (EQ-5D-3L) to 5-levels (EQ-5D-5L) would improve the descriptive richness and 
      ability of the measure to discriminate among different levels of health, and 2) 
      to examine the psychometric properties of each EQ-5D version in patients with 
      cancer. METHODS: U.S.-based cancer patients self-assessed their health using 
      EQ-5D-3L and EQ-5D-5L. These versions were compared in terms of ceiling effects, 
      convergent validity based on correlations with ECOG performance status and 
      FACT-G, discriminative ability using Rasch analysis, and informational richness 
      using Shannon's Evenness Index (J'). RESULTS: A ceiling effect was observed among 
      a greater proportion of respondents to EQ-5D-3L, n=74/424 (17%), compared with 
      EQ-5D-5L, n=47/424 (11%). Within the midlevel of EQ-5D-3L (some problems), 
      substantial partitioning of the sample into the 3 nonextreme levels of the 
      EQ-5D-5L was observed across dimensions. EQ-5D-5L demonstrated a trend towards 
      slightly stronger correlations with ECOG performance status compared with 
      EQ-5D-3L for all dimensions of health, ie, rs (5L/3L): rmobility=0.38/0.31; 
      rself-care=0.35/0.31; rusual activities=0.55/0.47; rpain/discomfort=0.43/0.37; 
      ranxiety/depression=0.23/0.16; rcrude summary score=0.56/0.49. EQ-5D-5L 
      demonstrated a greater relative efficiency and ability to discriminate different 
      levels of health. Informational richness and evenness of EQ-5D-5L was slightly 
      higher (J'5L=0.75) than EQ-5D-3L (J'3L=0.69). CONCLUSION: Evidence supported the 
      validity of both EQ-5D-3L and EQ-5D-5L in cancer. However, results suggest a 
      5-level classifier system has less ceiling effect and greater discriminative 
      ability with potentially more power to detect differences between groups compared 
      with EQ-5D-3L.
FAU - Pickard, A Simon
AU  - Pickard AS
AD  - Center for Pharmacoeconomic Research and Department of Pharmacy Practice, College 
      of Pharmacy, University of Illinois at Chicago 60612, and Midwest Center for 
      Health Services and Policy Research, Hines VA Hospital, Hines, Illinois, USA. 
      pickard1@uic.edu
FAU - De Leon, Maria C
AU  - De Leon MC
FAU - Kohlmann, Thomas
AU  - Kohlmann T
FAU - Cella, David
AU  - Cella D
FAU - Rosenbloom, Sarah
AU  - Rosenbloom S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Care
JT  - Medical care
JID - 0230027
SB  - IM
MH  - Activities of Daily Living/psychology
MH  - Depression/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*psychology
MH  - Pain/psychology
MH  - Psychometrics
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Self Care/psychology
MH  - *Surveys and Questionnaires
EDAT- 2007/02/17 09:00
MHDA- 2007/04/14 09:00
CRDT- 2007/02/17 09:00
PHST- 2007/02/17 09:00 [pubmed]
PHST- 2007/04/14 09:00 [medline]
PHST- 2007/02/17 09:00 [entrez]
AID - 00005650-200703000-00011 [pii]
AID - 10.1097/01.mlr.0000254515.63841.81 [doi]
PST - ppublish
SO  - Med Care. 2007 Mar;45(3):259-63. doi: 10.1097/01.mlr.0000254515.63841.81.