PMID- 17304353
OWN - NLM
STAT- MEDLINE
DCOM- 20070504
LR  - 20240505
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 117
IP  - 3
DP  - 2007 Mar
TI  - Shear stress-induced changes in atherosclerotic plaque composition are modulated 
      by chemokines.
PG  - 616-26
AB  - We previously found that low shear stress (LSS) induces atherosclerotic plaques 
      in mice with increased lipid and matrix metalloproteinase content and decreased 
      vascular smooth muscle and collagen content. Here, we evaluated the role of 
      chemokines in this process, using an extravascular device inducing regions of 
      LSS, high shear stress, and oscillatory shear stress (OSS) in the carotid artery. 
      One week of shear stress alterations induced expression of IFN-gamma-inducible 
      protein-10 (IP-10) exclusively in the LSS region, whereas monocyte 
      chemoattractant protein-1 (MCP-1) and the mouse homolog of growth-regulated 
      oncogene alpha (GRO-alpha) were equally upregulated in both LSS and OSS regions. 
      After 3 weeks, GRO-alpha and IP-10 were specifically upregulated in LSS regions. 
      After 9 weeks, lesions with thinner fibrous caps and larger necrotic cores were 
      found in the LSS region compared with the OSS region. Equal levels of MCP-1 
      expression were observed in both regions, while expression of fractalkine was 
      found in the LSS region only. Blockage of fractalkine inhibited plaque growth and 
      resulted in striking differences in plaque composition in the LSS region. We 
      conclude that LSS or OSS triggers expression of chemokines involved in 
      atherogenesis. Fractalkine upregulation is critically important for the 
      composition of LSS-induced atherosclerotic lesions.
FAU - Cheng, Caroline
AU  - Cheng C
AD  - Department of Cardiology, Thoraxcenter, Rotterdam, The Netherlands.
FAU - Tempel, Dennie
AU  - Tempel D
FAU - van Haperen, Rien
AU  - van Haperen R
FAU - de Boer, Hetty C
AU  - de Boer HC
FAU - Segers, Dolf
AU  - Segers D
FAU - Huisman, Martin
AU  - Huisman M
FAU - van Zonneveld, Anton Jan
AU  - van Zonneveld AJ
FAU - Leenen, Pieter J M
AU  - Leenen PJ
FAU - van der Steen, Anton
AU  - van der Steen A
FAU - Serruys, Patrick W
AU  - Serruys PW
FAU - de Crom, Rini
AU  - de Crom R
FAU - Krams, Rob
AU  - Krams R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070215
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Apolipoproteins E)
RN  - 0 (CX3C Chemokine Receptor 1)
RN  - 0 (Chemokines)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, HIV)
SB  - IM
MH  - Animals
MH  - Apolipoproteins E/genetics
MH  - Atherosclerosis/*etiology/pathology
MH  - CX3C Chemokine Receptor 1
MH  - Carotid Arteries/chemistry/*pathology
MH  - Carotid Artery Diseases/*etiology/pathology
MH  - Chemokines/genetics/*physiology
MH  - Gene Expression
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Receptors, Cytokine/analysis
MH  - Receptors, HIV/analysis
MH  - *Shear Strength
MH  - Stress, Mechanical
PMC - PMC1794116
EDAT- 2007/02/17 09:00
MHDA- 2007/05/05 09:00
PMCR- 2007/03/01
CRDT- 2007/02/17 09:00
PHST- 2006/02/09 00:00 [received]
PHST- 2006/12/19 00:00 [accepted]
PHST- 2007/02/17 09:00 [pubmed]
PHST- 2007/05/05 09:00 [medline]
PHST- 2007/02/17 09:00 [entrez]
PHST- 2007/03/01 00:00 [pmc-release]
AID - 28180 [pii]
AID - 10.1172/JCI28180 [doi]
PST - ppublish
SO  - J Clin Invest. 2007 Mar;117(3):616-26. doi: 10.1172/JCI28180. Epub 2007 Feb 15.