PMID- 17305280
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20170214
IS  - 0003-4894 (Print)
IS  - 0003-4894 (Linking)
VI  - 116
IP  - 1
DP  - 2007 Jan
TI  - Polymorphism between loci for human leukocyte antigens DR and DQ in patients with 
      nasal polyps.
PG  - 66-8
AB  - OBJECTIVES: We explored a potential association between nasal polyps (NPs) and 
      polymorphism at loci for human leukocyte antigen (HLA) DR and HLA-DQ. METHODS: 
      Polymorphism at loci HLA-DR and HLA-DQ were examined in 30 patients with NPs and 
      in 81 healthy subjects by use of the polymerase chain reaction-sequence specific 
      primer method. RESULTS: HLA-DR16, HLA-DQ8, and HLA-DQ9 were found to be 
      significantly associated with NPs. HLA-DR16, HLA-DQ8, and HLA-DQ9 specificities 
      were found at higher frequencies in patients with NPs than in control subjects 
      (5% versus 0.62%, RR = 8.9, p = .03; 10% versus 2.47%, RR = 4.81, p = .01; and 
      20% versus 6.18%, RR = 4.73%, p = .001; respectively). In contrast, HLA-DQ7 was 
      found at lower frequencies in patients with NPs than in controls (10% versus 
      20.37%, RR = 0.36, p = .04). CONCLUSIONS: We conclude that HLA-DR16, HLA-DQ8, and 
      HLA-DQ9 represent potential susceptibility determinants and that HLA-DQ7 might 
      confer resistance in nasal polyps.
FAU - Zhai, Lijie
AU  - Zhai L
AD  - Department of Otolaryngology, First Affiliated Hospital of Dalian Medical 
      University, Dalian. China.
FAU - Sun, Yiqing
AU  - Sun Y
FAU - Tang, Linghao
AU  - Tang L
FAU - Liu, Hui
AU  - Liu H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Nasal Polyps/*genetics/immunology
MH  - *Polymorphism, Genetic
EDAT- 2007/02/20 09:00
MHDA- 2007/03/21 09:00
CRDT- 2007/02/20 09:00
PHST- 2007/02/20 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2007/02/20 09:00 [entrez]
AID - 10.1177/000348940711600111 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2007 Jan;116(1):66-8. doi: 10.1177/000348940711600111.