PMID- 17306333
OWN - NLM
STAT- MEDLINE
DCOM- 20070525
LR  - 20151119
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 38
IP  - 5
DP  - 2007 May
TI  - Prognostic significance of stomatin-like protein 2 overexpression in laryngeal 
      squamous cell carcinoma: clinical, histologic, and immunohistochemistry analyses 
      with tissue microarray.
PG  - 747-52
AB  - Stomatin-like protein 2 (SLP-2) is a novel cancer-related gene whose product 
      promotes cell growth, tumorigenicity, and adhesion in human esophageal squamous 
      cell carcinoma. The purpose of this study was to investigate whether SLP-2 is 
      overexpressed in human laryngeal squamous cell carcinoma (LSCC) and, if so, the 
      significance of its overexpression in relation to clinical parameters. By 
      analyzing 124 cases of LSCC with a tissue microarray, we concluded that SLP-2 is 
      overexpressed in LSCC as compared with the adjacent normal laryngeal epithelium 
      (P = .000) and furthermore that SLP-2 expression correlates with clinical stage. 
      Overexpression can be regarded as a significant prognostic factor, with higher 
      expression being found in lymph node metastasis.
FAU - Cao, Wen-feng
AU  - Cao WF
AD  - Department of Pathology, Tianjin Medical University Cancer Institute and 
      Hospital, Tianjin, China.
FAU - Zhang, Li-yong
AU  - Zhang LY
FAU - Liu, Ming-bo
AU  - Liu MB
FAU - Tang, Ping-zhang
AU  - Tang PZ
FAU - Liu, Zhi-hua
AU  - Liu ZH
FAU - Sun, Bao-cun
AU  - Sun BC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070215
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Blood Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (STOML2 protein, human)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - Blood Proteins/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Mucosa/metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Membrane Proteins/*metabolism
MH  - Prognosis
MH  - Tissue Array Analysis
EDAT- 2007/02/20 09:00
MHDA- 2007/05/26 09:00
CRDT- 2007/02/20 09:00
PHST- 2006/05/19 00:00 [received]
PHST- 2006/09/18 00:00 [revised]
PHST- 2006/11/01 00:00 [accepted]
PHST- 2007/02/20 09:00 [pubmed]
PHST- 2007/05/26 09:00 [medline]
PHST- 2007/02/20 09:00 [entrez]
AID - S0046-8177(06)00658-7 [pii]
AID - 10.1016/j.humpath.2006.11.004 [doi]
PST - ppublish
SO  - Hum Pathol. 2007 May;38(5):747-52. doi: 10.1016/j.humpath.2006.11.004. Epub 2007 
      Feb 15.