PMID- 17306437
OWN - NLM
STAT- MEDLINE
DCOM- 20070817
LR  - 20070430
IS  - 0301-0511 (Print)
IS  - 0301-0511 (Linking)
VI  - 75
IP  - 2
DP  - 2007 May
TI  - Diminished medial prefrontal cortex activity in blood-injection-injury phobia.
PG  - 124-30
AB  - We examined the effects of symptom induction on neural activation in 
      blood-injection-injury (BII) phobia. Nine phobic and 10 non-phobic subjects 
      participated in an fMRI study in which they were presented with 
      disorder-relevant, generally disgust-inducing, generally fear-evoking and neutral 
      pictures. We observed diminished medial prefrontal cortex (MPFC) activity in 
      patients compared to controls for phobia-relevant and disgust-inducing pictures. 
      The MPFC has been shown to be critically involved in the automatic and effortful 
      cognitive regulation of emotions. Therefore, the results might reflect reduced 
      cognitive control of emotions in BII phobics during the experience of phobic 
      symptoms as well as during states of disgust. The latter response component might 
      be a result of the elevated disgust sensitivity of BII phobics.
FAU - Hermann, Andrea
AU  - Hermann A
AD  - Bender Institute of Neuroimaging, University of Giessen, Otto-Behaghel-Str. 10 H, 
      35394 Giessen, Germany. Andrea.Hermann@psychol.uni-giessen.de
FAU - Schafer, Axel
AU  - Schafer A
FAU - Walter, Bertram
AU  - Walter B
FAU - Stark, Rudolf
AU  - Stark R
FAU - Vaitl, Dieter
AU  - Vaitl D
FAU - Schienle, Anne
AU  - Schienle A
LA  - eng
PT  - Journal Article
DEP - 20070119
PL  - Netherlands
TA  - Biol Psychol
JT  - Biological psychology
JID - 0375566
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amygdala/physiopathology
MH  - Arousal/*physiology
MH  - *Blood
MH  - Brain Mapping
MH  - Cerebral Cortex/physiopathology
MH  - Dominance, Cerebral/physiology
MH  - Echo-Planar Imaging
MH  - Emotions/physiology
MH  - Fear/physiology
MH  - Female
MH  - Gyrus Cinguli/physiopathology
MH  - Hippocampus/physiopathology
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - Injections/*psychology
MH  - *Magnetic Resonance Imaging
MH  - Pattern Recognition, Visual/physiology
MH  - Personality Inventory
MH  - Phobic Disorders/*physiopathology/psychology
MH  - Prefrontal Cortex/*physiopathology
MH  - Syncope, Vasovagal/physiopathology/psychology
MH  - Thalamus/physiopathology
EDAT- 2007/02/20 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/02/20 09:00
PHST- 2007/01/16 00:00 [received]
PHST- 2007/01/16 00:00 [accepted]
PHST- 2007/02/20 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/02/20 09:00 [entrez]
AID - S0301-0511(07)00005-1 [pii]
AID - 10.1016/j.biopsycho.2007.01.002 [doi]
PST - ppublish
SO  - Biol Psychol. 2007 May;75(2):124-30. doi: 10.1016/j.biopsycho.2007.01.002. Epub 
      2007 Jan 19.