PMID- 17306505
OWN - NLM
STAT- MEDLINE
DCOM- 20070612
LR  - 20240312
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 91
IP  - 1-3
DP  - 2007 Mar
TI  - Brain derived neurotropic factor in first-episode psychosis.
PG  - 1-5
AB  - There is much interest, derived from current neurochemical, genetic, and 
      therapeutic research, in the role of brain neurotrophins in schizophrenia. 
      Neurotrophins play key roles in neuronal development and differentiation (i.e., 
      promoting dendritogenesis and synaptogenesis), and in orchestrating the neuronal 
      response to stress/noxious stimuli. Additionally, neurotrophins are modulators 
      across monominergic (dopamine and serotonin), gabaergic and cholinergic systems. 
      These roles focus on important areas of the etiopathophysiology of schizophrenia. 
      Clinical studies show reductions in brain-derived neurotrophic factor (BDNF) and 
      nerve growth factor (NFG) in schizophrenic patients as compared to normal control 
      subjects, as well as differences in patients receiving first-generation 
      antipsychotics (FGAs) or second-generation antipsychotics (SGAs). We now report 
      on BDNF levels in subjects with first-episode psychosis in comparison with normal 
      healthy controls. Compared to normal controls (N=14; 290.5+/-38.81 pg/ml), 
      first-episode psychotic patients showed significant reduction (N=15; 135+/-21.77 
      pg/ml; P=0.001; f=12.873) in plasma BDNF. Additionally, plasma BDNF levels showed 
      a significant negative correlation (N=13' r=0.584, P=0.0362) only with positive 
      symptom scores at base line and no significant correlations were found with any 
      of the cognitive performance test battery or motor function test scores. Low BDNF 
      levels at the onset of psychosis suggest that it may contribute to the 
      pathogenesis of schizophrenia and/or perhaps could be a helpful neurobiological 
      marker for possible early treatment intervention.
FAU - Buckley, Peter F
AU  - Buckley PF
AD  - Department of Psychiatry and Health Behavior, School of Medicine, Medical College 
      of Georgia, Augusta, GA 30912, USA. pbuckley@mail.mcg.edu
FAU - Pillai, Anilkumar
AU  - Pillai A
FAU - Evans, Denise
AU  - Evans D
FAU - Stirewalt, Edna
AU  - Stirewalt E
FAU - Mahadik, Sahebarao
AU  - Mahadik S
LA  - eng
GR  - R01 AT000147/AT/NCCIH NIH HHS/United States
GR  - AT000147/AT/NCCIH NIH HHS/United States
GR  - R01 AT000147-01/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070215
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Antibodies/immunology
MH  - Brain-Derived Neurotrophic Factor/*blood/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychotic Disorders/*blood/immunology/*psychology
MH  - Schizophrenia/blood/immunology
MH  - Time Factors
PMC - PMC1933504
MID - NIHMS20012
EDAT- 2007/02/20 09:00
MHDA- 2007/06/15 09:00
PMCR- 2008/03/01
CRDT- 2007/02/20 09:00
PHST- 2006/09/29 00:00 [received]
PHST- 2006/12/21 00:00 [revised]
PHST- 2006/12/27 00:00 [accepted]
PHST- 2007/02/20 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/02/20 09:00 [entrez]
PHST- 2008/03/01 00:00 [pmc-release]
AID - S0920-9964(07)00035-7 [pii]
AID - 10.1016/j.schres.2006.12.026 [doi]
PST - ppublish
SO  - Schizophr Res. 2007 Mar;91(1-3):1-5. doi: 10.1016/j.schres.2006.12.026. Epub 2007 
      Feb 15.