PMID- 17306836
OWN - NLM
STAT- MEDLINE
DCOM- 20070628
LR  - 20070319
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 80
IP  - 16
DP  - 2007 Mar 27
TI  - Repeated electroconvulsive stimuli have long-lasting effects on hippocampal BDNF 
      and decrease immobility time in the rat forced swim test.
PG  - 1539-43
AB  - Electroconvulsive therapy is considered an effective treatment for severe 
      depression. However, the mechanisms for its long-lasting antidepressant efficacy 
      are poorly understood. In the present study, we investigated changes of the 
      immobility time in the forced swim test and brain-derived neurotrophic factor 
      (BDNF) protein after withdrawal from 14-day repeated electroconvulsive stimuli 
      (ECS, 50 mA, 0.2 s) in rats. Immobility time in the forced swim test was markedly 
      decreased 6 h after withdrawal following 14-day ECS treatment. Thereafter, 
      prolongation of the withdrawal period gradually diminished the decreasing effect 
      of immobility time, but significant effects persisted for up to 3 days after the 
      withdrawal. Locomotor activity in the open-field test increased 6 h after 
      withdrawal from the ECS treatment, and the enhanced effect persisted for at least 
      7 days. The BDNF protein level in the hippocampus was markedly increased 6 h 
      after the withdrawal, and remained high for at least 7 days. These findings 
      provide further evidence that repeated ECS has long-lasting effect on increase in 
      BDNF and locomotor activity and decrease in immobility time in the forced swim 
      test.
FAU - Li, Bingjin
AU  - Li B
AD  - Department of Clinical Pharmacology and Pharmacy, Ehime University Graduate 
      School of Medicine, Shitsukawa Toon, Ehime, Japan.
FAU - Suemaru, Katsuya
AU  - Suemaru K
FAU - Cui, Ranji
AU  - Cui R
FAU - Araki, Hiroaki
AU  - Araki H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070127
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Electroconvulsive Therapy/*adverse effects
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*metabolism
MH  - Immobilization/physiology
MH  - Locomotion/*physiology
MH  - Rats
MH  - Swimming
EDAT- 2007/02/20 09:00
MHDA- 2007/06/29 09:00
CRDT- 2007/02/20 09:00
PHST- 2006/08/18 00:00 [received]
PHST- 2007/01/10 00:00 [revised]
PHST- 2007/01/15 00:00 [accepted]
PHST- 2007/02/20 09:00 [pubmed]
PHST- 2007/06/29 09:00 [medline]
PHST- 2007/02/20 09:00 [entrez]
AID - S0024-3205(07)00095-1 [pii]
AID - 10.1016/j.lfs.2007.01.032 [doi]
PST - ppublish
SO  - Life Sci. 2007 Mar 27;80(16):1539-43. doi: 10.1016/j.lfs.2007.01.032. Epub 2007 
      Jan 27.