PMID- 17309183
OWN - NLM
STAT- MEDLINE
DCOM- 20070322
LR  - 20161124
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 11
IP  - 4
DP  - 2006 Oct-Dec
TI  - Is there a role of whole body bone scan in early stages of non small cell lung 
      cancer patients.
PG  - 491-7
AB  - PURPOSE: The aim of our study was to re-evaluate the role of whole-body bone 
      scanning (WBBS) in detecting bone metastases in apparently operable stages of non 
      small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: We made a 
      retrospective analysis of 60 patients (53 males, 7 females, aged 47-87 years, 
      mean 68+/-4) between 2004-2006. All patients had a full series of imaging staging 
      procedures including WBBS. Their medical records were reviewed with respect to 
      how often bone metastases were detected and whether or not the patients showed 
      any symptoms or laboratory abnormalities indicating bone involvement. RESULTS: 
      Skeletal metastases (confirmed afterwards by x-ray, computed tomography or 
      biopsy) were found in 11 (18.3%) patients. All of them had normal serum alkaline 
      phosphatase and calcium concentrations. Eleven patients had symptoms suggesting 
      bone metastases and 49 were asymptomatic. Bone metastases were detected in 3 
      (27.2%) of 11 clinically symptom-positive patients and in 8 (16.3%) of 49 
      clinically symptom-negative patients. CONCLUSION: The present study indicates 
      that if bones scans were done only in patients reporting skeletal symptoms an 
      important number of patients (16.3%) would have been misstaged due to 
      asymptomatic bone metastases. We conclude that in patients with apparently 
      operable NSCLC preoperative staging using WBBS is useful to avoid under-staging 
      and futile surgery.
FAU - Iordanidou, L
AU  - Iordanidou L
AD  - Department of Nuclear Medicine, Metaxa Cancer Hospital, Piraeus, Greece. 
      lydiaior@otenet.gr
FAU - Trivizaki, E
AU  - Trivizaki E
FAU - Saranti, S
AU  - Saranti S
FAU - Georgakopoulos, A
AU  - Georgakopoulos A
FAU - Bolanos, N
AU  - Bolanos N
FAU - Baltagiannis, N
AU  - Baltagiannis N
FAU - Koutsiouba, P
AU  - Koutsiouba P
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
RN  - 0 (Diphosphonates)
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (technetium 99m methylene bisphosphonate)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alkaline Phosphatase/blood
MH  - Bone Neoplasms/*diagnostic imaging/secondary
MH  - Carcinoma, Non-Small-Cell Lung/*diagnostic imaging/secondary
MH  - Diphosphonates
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Organotechnetium Compounds
MH  - Predictive Value of Tests
MH  - Radionuclide Imaging
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
MH  - *Whole Body Imaging
EDAT- 2007/02/20 09:00
MHDA- 2007/03/23 09:00
CRDT- 2007/02/20 09:00
PHST- 2007/02/20 09:00 [pubmed]
PHST- 2007/03/23 09:00 [medline]
PHST- 2007/02/20 09:00 [entrez]
PST - ppublish
SO  - J BUON. 2006 Oct-Dec;11(4):491-7.