PMID- 17309526
OWN - NLM
STAT- MEDLINE
DCOM- 20070508
LR  - 20131121
IS  - 1742-7835 (Print)
IS  - 1742-7835 (Linking)
VI  - 100
IP  - 3
DP  - 2007 Mar
TI  - Fritillaria cirrhosa, Anemarrhena asphodeloides, Lee-Mo-Tang and cyclosporine a 
      inhibit ovalbumin-induced eosinophil accumulation and Th2-mediated bronchial 
      hyperresponsiveness in a murine model of asthma.
PG  - 205-13
AB  - Asthma is a chronic inflammatory disorder of the airways characterized by excess 
      production of Th2 cytokines and eosinophil accumulation in the lungs. Fritillaria 
      cirrhosa, Anemarrhena asphodeloides and Lee-Mo-Tang are well-known herbs used in 
      oriental medicine for the treatment of asthma and bronchial inflammation. To 
      clarify the anti-asthmatic effects of Fritillaria cirrhosa bulbus, Anemarrhena 
      rhizoma and Lee-Mo-Tang, we examined the development of pulmonary eosinophilic 
      accumulation, control of Th2 cytokine, immunoglobulin E (IgE) and histamine 
      productions in a murine model of asthma. Eosinophil cell proliferation was 
      performed by [(3)H]thymidine uptake, eosinophilic accumulation. Cell counts in 
      bronchoalveolar lavage fluid were investigated by means of fluorescence activated 
      cell sorter analysis and control of Th2 cytokine, IgE and histamine productions 
      were investigated by RT-PCR and ELISA. Moreover, lung tissue was histologically 
      analysed. The suppressive effects of Fritillaria cirrhosa bulbus, Anemarrhena 
      rhizoma and Lee-Mo-Tang on eosinophil recruitment and airway inflammation were 
      demonstrated throughout the reduction of eosinophil numbers. This result 
      correlated with a marked reduction IL-5, IL-13 and IL-4 levels in the 
      bronchoalveolar lavage fluid. Ovalbumin-specific IgE levels were also decreased 
      in serum. Fritillaria cirrhosa bulbus, Anemarrhena rhizoma and Lee-Mo-Tang have 
      deep inhibitory effects on airway inflammation by suppression of Th2 cytokines 
      (IL-4, IL-5 and IL-13), IgE, histamine production, reduction eosinophilic 
      accumulation and increase of interferon-gamma production.
FAU - Yeum, Hyun-Shiek
AU  - Yeum HS
AD  - Department of Herbology, College of Oriental Medicine, Sangji University, Wonju, 
      South Korea.
FAU - Lee, Young-Cheol
AU  - Lee YC
FAU - Kim, Seung-Hyung
AU  - Kim SH
FAU - Roh, Seong-Soo
AU  - Roh SS
FAU - Lee, Jang-Cheon
AU  - Lee JC
FAU - Seo, Young-Bae
AU  - Seo YB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Interleukins)
RN  - 0 (Plant Preparations)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
EIN - Basic Clin Pharmacol Toxicol. 2007 May;100(5):360
MH  - Anemarrhena/chemistry
MH  - Animals
MH  - Anti-Asthmatic Agents/*pharmacology/therapeutic use
MH  - Asthma/*drug therapy/immunology
MH  - Bronchial Hyperreactivity/drug therapy/immunology
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - Cell Proliferation/drug effects
MH  - Cyclosporine/*pharmacology/therapeutic use
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Eosinophilia/drug therapy/immunology
MH  - Flow Cytometry
MH  - Fritillaria/chemistry
MH  - Herbal Medicine
MH  - Histamine/metabolism
MH  - Immunoglobulin E/metabolism
MH  - Interferon-gamma/drug effects/metabolism
MH  - Interleukins/metabolism
MH  - Lung/drug effects/physiopathology
MH  - Male
MH  - Mice
MH  - Ovalbumin/toxicity
MH  - *Phytotherapy
MH  - Plant Preparations/*pharmacology/therapeutic use
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2007/02/21 09:00
MHDA- 2007/05/09 09:00
CRDT- 2007/02/21 09:00
PHST- 2007/02/21 09:00 [pubmed]
PHST- 2007/05/09 09:00 [medline]
PHST- 2007/02/21 09:00 [entrez]
AID - PTO043 [pii]
AID - 10.1111/j.1742-7843.2007.00043.x [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2007 Mar;100(3):205-13. doi: 
      10.1111/j.1742-7843.2007.00043.x.