PMID- 17309544 OWN - NLM STAT- MEDLINE DCOM- 20070515 LR - 20070323 IS - 1470-0328 (Print) IS - 1470-0328 (Linking) VI - 114 IP - 4 DP - 2007 Apr TI - Human papillomavirus infection and primary fallopian tube carcinoma: a seroepidemiological study. PG - 425-9 AB - OBJECTIVE: To evaluate the role of human papillomavirus (HPV) types 6, 11, 16, 18, 31 or 33 infection in primary fallopian tube carcinoma (PFTC). DESIGN: A retrospective case-control study. SETTING: Department of Obstetrics and Gynaecology, Helsinki University Hospital, Finland. POPULATION: Seventy-eight consecutive women with PFTC diagnosed between 1985 and 2000 were studied. For each case, two healthy controls were selected. METHODS: Serum immunoglobulin G antibodies to HPV types 6, 11, 16, 18, 31 and 33 were measured from women with PFTC and their healthy controls. MAIN OUTCOME MEASURES: Analysis of HPV 6, 11, 18, 31 and 33 seropositivity among women with PFTC and controls. RESULTS: Seropositivity rates of non-oncogenic or oncogenic HPV types did not differ between cases and controls, odds ratios being 1.04-1.30 for oncogenic HPVs and 1.08-1.19 for non-oncogenic HPVs, similarly. We did not find any multiplicative joint effect in PFTC by antibodies to more than one oncogenic HPV type; neither did we find any antagonistic effect among women with antibodies to non-oncogenic and oncogenic HPV types. CONCLUSIONS: Our results do not suggest any link between PFTC and serological evidence for HPV infection. FAU - Riska, A AU - Riska A AD - Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland. annika.riska@pp.inet.fi FAU - Finne, P AU - Finne P FAU - Koskela, P AU - Koskela P FAU - Alfthan, H AU - Alfthan H FAU - Jalkanen, J AU - Jalkanen J FAU - Lehtinen, M AU - Lehtinen M FAU - Sorvari, T AU - Sorvari T FAU - Stenman, U-H AU - Stenman UH FAU - Paavonen, J AU - Paavonen J FAU - Leminen, A AU - Leminen A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20070219 PL - England TA - BJOG JT - BJOG : an international journal of obstetrics and gynaecology JID - 100935741 RN - 0 (Antibodies, Viral) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Alphapapillomavirus/immunology MH - Antibodies, Viral/blood MH - Case-Control Studies MH - Enzyme-Linked Immunosorbent Assay MH - Fallopian Tube Neoplasms/*virology MH - Female MH - Humans MH - Middle Aged MH - Papillomavirus Infections/*complications MH - Retrospective Studies MH - Seroepidemiologic Studies EDAT- 2007/02/21 09:00 MHDA- 2007/05/16 09:00 CRDT- 2007/02/21 09:00 PHST- 2007/02/21 09:00 [pubmed] PHST- 2007/05/16 09:00 [medline] PHST- 2007/02/21 09:00 [entrez] AID - BJO1256 [pii] AID - 10.1111/j.1471-0528.2006.01256.x [doi] PST - ppublish SO - BJOG. 2007 Apr;114(4):425-9. doi: 10.1111/j.1471-0528.2006.01256.x. Epub 2007 Feb 19.