PMID- 17310113
OWN - NLM
STAT- MEDLINE
DCOM- 20070403
LR  - 20190212
IS  - 1015-8987 (Print)
IS  - 1015-8987 (Linking)
VI  - 19
IP  - 1-4
DP  - 2007
TI  - Sex differences in brown adipose tissue thermogenic features during caloric 
      restriction.
PG  - 195-204
AB  - Caloric restriction (CR) studies have shown that females rats conserve energy 
      more efficiently, showing a higher resistance to weight loss and higher 
      protection of vital organs mass than male rats. Gender-dependent inactivation of 
      thermogenesis in brown adipose tissue (BAT) has been proposed as one of these 
      possible energy conserving mechanisms. To study the changes underlying this 
      inactivation in rats, a three month study with 40% CR was undertaken to unravel 
      the effects on BAT recruitment. Under ad libitum conditions female rats had 
      greater BAT recruitment and greater oxygen consumption than their male 
      counterparts. Total and mitochondrial protein, as well as triglyceride and DNA 
      content were more reduced in restricted female rats than in restricted males. 
      Similarly, the levels of key BAT functional proteins (UCP1, LPL, HSL, TFAM) were 
      more reduced in restricted females, whereas no changes were found in 
      mitochondrial DNA levels (mtDNA) and OXPHOS activities in males and females. 
      Furthermore, alpha (2A)/beta (3) adrenergic receptor ratio remained constant in 
      male rats whereas in female rats CR increased 60%. In conclusion, our results 
      suggest that female rats, whose BAT thermogenic activity is higher in ad libitum 
      conditions, is depressed during CR. This inactivation involves the mitochondrial 
      differentiation process and lipolytic system and could be due, at least in part, 
      to the unfavourable adrenergic receptor balance for thermogenic activation.
CI  - Copyright 2007 S. Karger AG, Basel.
FAU - Valle, Adamo
AU  - Valle A
AD  - Grup de Metabolisme Energetic i Nutricio. Departament de Biologia Fonamental i 
      Ciencies de la Salut. Institut Universitari d'Investigacio en Ciencies de la 
      Salut (IUNICS). Universitat de les Illes Balears, Palma de Mallorca, Spain.
FAU - Garcia-Palmer, Francisco J
AU  - Garcia-Palmer FJ
FAU - Oliver, Jordi
AU  - Oliver J
FAU - Roca, Pilar
AU  - Roca P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Ion Channels)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Receptors, Adrenergic)
RN  - 0 (TFAM protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (UCP1 protein, human)
RN  - 0 (Ucp1 protein, rat)
RN  - 0 (Uncoupling Protein 1)
RN  - EC 3.1.1.13 (Sterol Esterase)
RN  - EC 3.1.1.34 (Lipoprotein Lipase)
SB  - IM
MH  - Adipose Tissue, Brown/*chemistry/enzymology
MH  - Animals
MH  - Body Mass Index
MH  - Body Weight
MH  - *Caloric Restriction
MH  - DNA, Mitochondrial/*metabolism
MH  - DNA-Binding Proteins/metabolism
MH  - Female
MH  - Ion Channels/metabolism
MH  - Lipoprotein Lipase/metabolism
MH  - Male
MH  - Mitochondrial Proteins/metabolism
MH  - Oxidative Phosphorylation
MH  - Oxygen Consumption
MH  - Rats
MH  - Receptors, Adrenergic/metabolism
MH  - Sex Factors
MH  - Sterol Esterase/metabolism
MH  - *Thermogenesis
MH  - Transcription Factors/metabolism
MH  - Uncoupling Protein 1
EDAT- 2007/02/21 09:00
MHDA- 2007/04/04 09:00
CRDT- 2007/02/21 09:00
PHST- 2006/09/15 00:00 [accepted]
PHST- 2007/02/21 09:00 [pubmed]
PHST- 2007/04/04 09:00 [medline]
PHST- 2007/02/21 09:00 [entrez]
AID - 000099207 [pii]
AID - 10.1159/000099207 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2007;19(1-4):195-204. doi: 10.1159/000099207.