PMID- 17311339
OWN - NLM
STAT- MEDLINE
DCOM- 20070405
LR  - 20111117
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 79
IP  - 4
DP  - 2007 Apr
TI  - HPV16 E6 variants and HLA class II polymorphism among Chinese women with cervical 
      cancer.
PG  - 439-46
AB  - Infection with human papillomavirus type 16 (HPV16) confers a high risk for the 
      development of cervical cancer. Variants of this virus may interact 
      differentially with host genetic factors, possibly affecting the disease 
      pathogenesis. This study was designed to investigate the association between 
      HPV16 E6 variants and human leukocyte antigen (HLA) polymorphism within a Chinese 
      population. Peripheral blood from HPV16 positive Chinese women with cervical 
      carcinoma, who had previously been tested for HPV16 E6 variants, was used for HLA 
      class II typing. It was found that there was a significant positive association 
      between DQB1*060101 allele and HPV16 As variant-positive cervical cancers (OR, 
      4.47; Pc=0.0018). A negative relationship was found between DRB1*150101-DQB1*0602 
      haplotype and decreased risk for HPV16 As variant-positive cervical cancers 
      (OR=0.31; P=0.037). Similar tendency was observed for the haplotype 
      DRB1*070101-DQB1*0201 with HPV16 As variant-positive cervical cancers (OR=0.16, 
      P=0.024). Additionally, as for the HPV16 E6 prototype-positive cervical cancers, 
      a significant positive association was found in DQB1*060101 allele (OR=5.95; 
      P=0.002; Pc=0.036), and similar trends were observed for DQB1*030201 (OR=10.87, 
      P<0.0001; Pc=0.0018), and DPB1*1301(OR=7.40, P=0.002; Pc=0.04). It was found that 
      there was no significant association between DRB1-DQB1 haplotype and HPV16 
      prototype-positive cervical cancers. These data indicate that host genetic 
      factors, such as HLA polymorphism, may determine the potential oncogenicity of 
      the HPV16 E6 variant. The results suggest that a specific match between E6 
      variant proteins and HLA class II alleles may contribute to HPV16-related 
      cervical carcinogenesis in a certain Chinese population.
CI  - (c) 2007 Wiley-Liss, Inc.
FAU - Wu, Yuping
AU  - Wu Y
AD  - Department of Biochemistry, State Key Laboratory of Biocontrol, College of Life 
      Sciences, Sun Yat-Sen (Zhongshan) University, Guangzhou, P. R. China.
FAU - Liu, Benrong
AU  - Liu B
FAU - Lin, Wenzhi
AU  - Lin W
FAU - Xu, Yunping
AU  - Xu Y
FAU - Li, Longyu
AU  - Li L
FAU - Zhang, Yanling
AU  - Zhang Y
FAU - Chen, Shangwu
AU  - Chen S
FAU - Xu, Anlong
AU  - Xu A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (E6 protein, Human papillomavirus type 16)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQbeta antigen)
RN  - 0 (Oncogene Proteins, Viral)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Alleles
MH  - Carcinoma/*genetics/*virology
MH  - China
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Oncogene Proteins, Viral/*genetics
MH  - Repressor Proteins/*genetics
MH  - Uterine Cervical Neoplasms/*genetics/*virology
EDAT- 2007/02/22 09:00
MHDA- 2007/04/06 09:00
CRDT- 2007/02/22 09:00
PHST- 2007/02/22 09:00 [pubmed]
PHST- 2007/04/06 09:00 [medline]
PHST- 2007/02/22 09:00 [entrez]
AID - 10.1002/jmv.20785 [doi]
PST - ppublish
SO  - J Med Virol. 2007 Apr;79(4):439-46. doi: 10.1002/jmv.20785.