PMID- 17311605
OWN - NLM
STAT- MEDLINE
DCOM- 20070629
LR  - 20131121
IS  - 0269-2813 (Print)
IS  - 0269-2813 (Linking)
VI  - 25
IP  - 6
DP  - 2007 Mar 15
TI  - Long-term treatment of patients with gastro-oesophageal reflux disease in routine 
      care - results from the ProGERD study.
PG  - 715-22
AB  - BACKGROUND: Gastro-oesophageal reflux disease (GERD) is a common condition 
      frequently requiring long-term pharmacological treatment. AIM: To describe the 
      long-term pattern of GERD medication use in GERD patients receiving routine care. 
      METHODS: Patients were recruited as part of the ongoing ProGERD study, a 
      10-year-cohort study including 6215 patients at baseline. GERD medication and 
      symptoms were assessed with patient questionnaires. During follow-up, medical 
      treatment was prescribed by participating primary care physicians. Associations 
      between patient characteristics and medication were analysed by logistic 
      regression. RESULTS: The percentage of patients who reported using any GERD 
      medication remained constant from year 1 to year 4 (74%, 74%, 73% and 71%). Of 
      patients who reported using GERD medication, the majority were taking proton pump 
      inhibitors (PPI) (79%, 84%, 85%, and 87%). Continuous PPI intake was the 
      predominant prescription pattern (53%, 49%, 56% and 56%), followed by on-demand 
      treatment (26%, 35%, 29% and 29%). Continuous PPI intake was strongly associated 
      with the presence of erosive GERD. CONCLUSION: Three-quarters of the GERD 
      population in our study reported long-term treatment with a PPI. Continuous PPI 
      intake was the predominant treatment pattern, and the proportion of patients 
      taking a PPI on a continuous basis remained constant over time.
FAU - Nocon, M
AU  - Nocon M
AD  - Institute for Social Medicine, Epidemiology, and Health Economics, Charite 
      University Medical Center, Berlin, Germany. marc.nocon@charite.de
FAU - Labenz, J
AU  - Labenz J
FAU - Jaspersen, D
AU  - Jaspersen D
FAU - Meyer-Sabellek, W
AU  - Meyer-Sabellek W
FAU - Stolte, M
AU  - Stolte M
FAU - Lind, T
AU  - Lind T
FAU - Malfertheiner, P
AU  - Malfertheiner P
FAU - Willich, S N
AU  - Willich SN
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Cohort Studies
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Humans
MH  - Long-Term Care
MH  - Male
MH  - Middle Aged
MH  - *Proton Pump Inhibitors
EDAT- 2007/02/22 09:00
MHDA- 2007/06/30 09:00
CRDT- 2007/02/22 09:00
PHST- 2007/02/22 09:00 [pubmed]
PHST- 2007/06/30 09:00 [medline]
PHST- 2007/02/22 09:00 [entrez]
AID - APT3249 [pii]
AID - 10.1111/j.1365-2036.2007.03249.x [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2007 Mar 15;25(6):715-22. doi: 
      10.1111/j.1365-2036.2007.03249.x.