PMID- 17312085
OWN - NLM
STAT- MEDLINE
DCOM- 20070418
LR  - 20150615
IS  - 1545-9683 (Print)
IS  - 1545-9683 (Linking)
VI  - 21
IP  - 2
DP  - 2007 Mar-Apr
TI  - Resistance training with creatine monohydrate improves upper-body strength in 
      patients with Parkinson disease: a randomized trial.
PG  - 107-15
AB  - BACKGROUND: Persons with Parkinson disease (PD) exhibit decreased muscular 
      fitness including decreased muscle mass, muscle strength, bioenergetic 
      capabilities and increased fatigability. OBJECTIVE: This purpose of this 
      investigation was to evaluate the therapeutic effects of resistance training with 
      and without creatine supplementation in patients with mild to moderate PD. 
      METHODS: Twenty patients with idiopathic PD were randomized to receive creatine 
      monohydrate supplementation plus resistance training (CRE) or placebo (lactose 
      monohydrate) plus resistance training (PLA), using a double-blind procedure. 
      Creatine and placebo supplementation consisted of 20 g/d for the first 5 days and 
      5 g/d thereafter. Both groups participated in progressive resistance training (24 
      sessions, 2 times per week, 1 set of 8-12 repetitions, 9 exercises). Participants 
      performed 1-repetition maximum (1-RM) for chest press, leg extension, and biceps 
      curl. Muscular endurance was evaluated for chest press and leg extension as the 
      number of repetitions to failure using 60% of baseline 1-RM. Functional 
      performance was evaluated as the time to perform 3 consecutive chair rises. 
      RESULTS: Statistical analyses (ANOVA) revealed significant Group x Time 
      interactions for chest press strength and biceps curl strength, and post hoc 
      testing revealed that the improvement was significantly greater for CRE. Chair 
      rise performance significantly improved only for CRE (12%, P=.03). Both PLA and 
      CRE significantly improved 1-RM for leg extension (PLA: 16%; CRE: 18%). Muscular 
      endurance improved significantly for both groups. CONCLUSIONS: These findings 
      demonstrate that creatine supplementation can enhance the benefits of resistance 
      training in patients with PD.
FAU - Hass, Chris J
AU  - Hass CJ
AD  - Department of Biobehavioral Sciences, Teachers College, Columbia University, New 
      York, NY, USA. cjhass@hhp.ufl.edu
FAU - Collins, Mitchell A
AU  - Collins MA
FAU - Juncos, Jorge L
AU  - Juncos JL
LA  - eng
GR  - 5 P30 AT000609-04/AT/NCCIH NIH HHS/United States
GR  - R0-1 AT00612-04/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurorehabil Neural Repair
JT  - Neurorehabilitation and neural repair
JID - 100892086
RN  - 0 (Placebos)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Administration, Oral
MH  - Aged
MH  - Body Composition
MH  - Combined Modality Therapy
MH  - Creatine/*administration & dosage
MH  - Dietary Supplements
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Activity
MH  - Muscle Strength/*drug effects/physiology
MH  - Parkinson Disease/*drug therapy/physiopathology/*rehabilitation
MH  - Physical Endurance/drug effects
MH  - Placebos
MH  - Treatment Outcome
EDAT- 2007/02/22 09:00
MHDA- 2007/04/19 09:00
CRDT- 2007/02/22 09:00
PHST- 2007/02/22 09:00 [pubmed]
PHST- 2007/04/19 09:00 [medline]
PHST- 2007/02/22 09:00 [entrez]
AID - 21/2/107 [pii]
AID - 10.1177/1545968306293449 [doi]
PST - ppublish
SO  - Neurorehabil Neural Repair. 2007 Mar-Apr;21(2):107-15. doi: 
      10.1177/1545968306293449.