PMID- 17313515
OWN - NLM
STAT- MEDLINE
DCOM- 20070409
LR  - 20131121
IS  - 1360-2276 (Print)
IS  - 1360-2276 (Linking)
VI  - 12
IP  - 3
DP  - 2007 Mar
TI  - Associations between specific antibody responses and resistance to reinfection in 
      a Senegalese population recently exposed to Schistosoma mansoni.
PG  - 431-44
AB  - We examined associations between schistosome-specific antibody responses and 
      reinfection in Senegalese individuals recently exposed to Schistosoma mansoni. 
      The effects of treatment, age, intensity of infection and duration of exposure on 
      schistosome-specific antibody responses were also investigated by comparing 
      immune responses in individuals exposed for less than 3 years with responses in 
      people exposed for more than 8 years. All individuals were bled before treatment 
      as well as 6 and 12 weeks after. We used a statistical model that included 
      interaction terms between time, age, infection intensity and duration of 
      exposure. The overall patterns of most specific antibody responses by age were 
      similar to those previously published for S. mansoni, Schistosoma japonicum and 
      Schistosoma haematobium infections in different endemic areas. In general, a 
      boost in specific antibody responses against adult worm antigen (SWA) was 
      observed at 6 weeks after treatment whereas the majority of isotype responses 
      against egg antigen (SEA) were not affected by treatment. Our analysis showed 
      that the effect of treatment on schistosome-specific antibody responses is 
      influenced by age, infection intensity and duration of exposure. We found no 
      evidence that treatment matures the specific antibody response of children 
      recently infected with S. mansoni. Our results indicate that the build-up of 
      potentially protective immunoglobulin E (IgE) responses was associated with 
      duration of exposure, or, in other words, experience of infection. Interestingly, 
      in recently exposed individuals there was a significant association between IgA 
      responses to SWA and resistance to reinfection. Resistance to reinfection and 
      production of IgA-SWA was associated with adulthood independently of exposure 
      patterns, suggesting that susceptibility to S. mansoni and the development of 
      protective immune responses is age-dependent.
FAU - Vereecken, Kim
AU  - Vereecken K
AD  - Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium.
FAU - Naus, Cynthia W A
AU  - Naus CW
FAU - Polman, Katja
AU  - Polman K
FAU - Scott, Janet T
AU  - Scott JT
FAU - Diop, Mamadou
AU  - Diop M
FAU - Gryseels, Bruno
AU  - Gryseels B
FAU - Kestens, Luc
AU  - Kestens L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Trop Med Int Health
JT  - Tropical medicine & international health : TM & IH
JID - 9610576
RN  - 0 (Anthelmintics)
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Immunoglobulins)
RN  - 6490C9U457 (Praziquantel)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Anthelmintics/therapeutic use
MH  - Antibodies, Helminth/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Disease Outbreaks
MH  - Female
MH  - Humans
MH  - Immunoglobulins
MH  - Male
MH  - Middle Aged
MH  - Population Surveillance/methods
MH  - Praziquantel/therapeutic use
MH  - Prevalence
MH  - Recurrence
MH  - Rural Health
MH  - Schistosomiasis mansoni/drug therapy/epidemiology/*immunology
MH  - Senegal/epidemiology
MH  - Time Factors
EDAT- 2007/02/23 09:00
MHDA- 2007/04/10 09:00
CRDT- 2007/02/23 09:00
PHST- 2007/02/23 09:00 [pubmed]
PHST- 2007/04/10 09:00 [medline]
PHST- 2007/02/23 09:00 [entrez]
AID - TMI1805 [pii]
AID - 10.1111/j.1365-3156.2006.01805.x [doi]
PST - ppublish
SO  - Trop Med Int Health. 2007 Mar;12(3):431-44. doi: 
      10.1111/j.1365-3156.2006.01805.x.