PMID- 17313562
OWN - NLM
STAT- MEDLINE
DCOM- 20070327
LR  - 20131121
IS  - 0902-4441 (Print)
IS  - 0902-4441 (Linking)
VI  - 78
IP  - 2
DP  - 2007 Feb
TI  - Graft rejection and hyperacute graft-versus-host disease in stem cell 
      transplantation from non-inherited maternal-antigen-complementary HLA-mismatched 
      siblings.
PG  - 157-60
AB  - Human leukocyte antigen (HLA)-mismatched stem cell transplantation from 
      non-inherited maternal antigen (NIMA)-complementary donors is known to produce 
      stable engraftment without inducing severe graft-versus-host disease (GVHD). We 
      treated two patients with acute myeloid leukemia (AML) and one patient with 
      severe aplastic anemia (SAA) with HLA-mismatched stem cell transplantation (SCT) 
      from NIMA-complementary donors (NIMA-mismatched SCT). The presence of donor and 
      recipient-derived blood cells in the peripheral blood of recipient (donor 
      microchimerism) and donor was documented respectively by amplifying NIMA-derived 
      DNA in two of the three patients. Graft rejection occurred in the SAA patient who 
      was conditioned with a fludarabine-based regimen. Grade III and grade IV acute 
      GVHD developed in patients with AML on day 8 and day 11 respectively, and became 
      a direct cause of death in one patient. The findings suggest that intensive 
      conditioning and immunosuppression after stem cell transplantation are needed in 
      NIMA-mismatched SCT even if donor and recipient microchimerisms is detectable in 
      the donor and recipient before SCT.
FAU - Okumura, Hirokazu
AU  - Okumura H
AD  - Department of Cellular Transplantation Biology, Kanazawa University Graduate 
      School of Medical Science, Kanazawa, Japan. hokumura@med3.m.kanazawa-u.ac.jp
FAU - Yamaguchi, Masaki
AU  - Yamaguchi M
FAU - Kotani, Takeharu
AU  - Kotani T
FAU - Sugimori, Naomi
AU  - Sugimori N
FAU - Sugimori, Chiharu
AU  - Sugimori C
FAU - Ozaki, Jun
AU  - Ozaki J
FAU - Kondo, Yukio
AU  - Kondo Y
FAU - Yamazaki, Hirohito
AU  - Yamazaki H
FAU - Chuhjo, Tatsuya
AU  - Chuhjo T
FAU - Takami, Akiyoshi
AU  - Takami A
FAU - Ueda, Mikio
AU  - Ueda M
FAU - Ohtake, Shigeki
AU  - Ohtake S
FAU - Nakao, Shinji
AU  - Nakao S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantigens)
RN  - FA2DM6879K (Vidarabine)
RN  - P2K93U8740 (fludarabine)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Anemia, Aplastic/immunology/pathology/*surgery
MH  - Blast Crisis/immunology/pathology/*surgery
MH  - Chimera/genetics/*immunology
MH  - Cord Blood Stem Cell Transplantation
MH  - Disease Progression
MH  - Fatal Outcome
MH  - Female
MH  - Graft Rejection/genetics/*immunology
MH  - Graft vs Host Disease/genetics/*immunology/prevention & control
MH  - HLA Antigens/*genetics/immunology
MH  - Histocompatibility
MH  - Humans
MH  - *Immunity, Maternally-Acquired
MH  - Isoantigens/immunology
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology/pathology/*surgery
MH  - Leukemia, Myeloid/drug therapy/pathology
MH  - Male
MH  - Peripheral Blood Stem Cell Transplantation/*adverse effects
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology/pathology/*surgery
MH  - Remission Induction
MH  - Siblings
MH  - *Tissue Donors
MH  - Transplantation Conditioning/*methods
MH  - Vidarabine/administration & dosage/analogs & derivatives
EDAT- 2007/02/23 09:00
MHDA- 2007/03/28 09:00
CRDT- 2007/02/23 09:00
PHST- 2007/02/23 09:00 [pubmed]
PHST- 2007/03/28 09:00 [medline]
PHST- 2007/02/23 09:00 [entrez]
AID - EJH797 [pii]
AID - 10.1111/j.1600-0609.2006.00797.x [doi]
PST - ppublish
SO  - Eur J Haematol. 2007 Feb;78(2):157-60. doi: 10.1111/j.1600-0609.2006.00797.x.