PMID- 17314108
OWN - NLM
STAT- MEDLINE
DCOM- 20071109
LR  - 20220316
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 28
IP  - 5
DP  - 2007 Mar
TI  - Prognostic value of the 6 min walk test and self-perceived symptom severity in 
      older patients with chronic heart failure.
PG  - 560-8
AB  - BACKGROUND: The 6 min walk test (6-MWT) is a simple and popular test for 
      evaluating functional status in patients with chronic heart failure (CHF). 
      However, the prognostic value of the 6-MWT in a large, representative sample of 
      CHF patients, and in patients with different degrees of left ventricular systolic 
      dysfunction (LVSD) remains unclear. METHODS AND RESULTS: Of an initial population 
      of 1592 patients, 212 died representing a crude death rate of 13.3%. In surviving 
      patients, the median time to follow-up period was 36.6 months [inter-quartile 
      range (IQR) 28-45 months]. Five variables remained independent predictors of 
      all-cause mortality; decreasing 6-MWT distance, self-perceived signs of 
      breathlessness at night (SOBAN), beta-blocker usage, elevated log NT-proBNP, and 
      reduced haemoglobin concentration. We also dichotomized our analysis by LVSD 
      status (<or=mild LVSD or >mild LVSD). For patients with >mild LVSD, 6-MWT 
      remained an important prognostic indicator but not in patients with <or=mild 
      LVSD. CONCLUSION: The 6-MWT is an important independent predictor of mortality in 
      CHF patients, and this was especially evident in patients with >mild LVSD. The 
      6-MWT provides little prognostic utility in patients with <or=mild LVSD. While 
      log NT-proBNP was the most potent independent predictor, an additive prognostic 
      effect was evident with the additional selection of 6-MWT. Patients' 
      self-perceived symptoms, especially SOBAN was an independent predictor of 
      mortality in our patients.
FAU - Ingle, Lee
AU  - Ingle L
AD  - Carnegie Research Institute, Leeds Metropolitan University, Beckett's Park 
      Campus, Leeds LS6 3QS, UK.
FAU - Rigby, Alan S
AU  - Rigby AS
FAU - Carroll, Sean
AU  - Carroll S
FAU - Butterly, Ron
AU  - Butterly R
FAU - King, Rod F
AU  - King RF
FAU - Cooke, Carlton B
AU  - Cooke CB
FAU - Cleland, John G J F
AU  - Cleland JG
FAU - Clark, Andrew L
AU  - Clark AL
LA  - eng
PT  - Journal Article
DEP - 20070221
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/*mortality/physiopathology
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Regression Analysis
MH  - Survival Analysis
MH  - Ventricular Dysfunction, Left/*mortality/physiopathology
MH  - Walking/*physiology
EDAT- 2007/02/23 09:00
MHDA- 2007/11/10 09:00
CRDT- 2007/02/23 09:00
PHST- 2007/02/23 09:00 [pubmed]
PHST- 2007/11/10 09:00 [medline]
PHST- 2007/02/23 09:00 [entrez]
AID - ehl527 [pii]
AID - 10.1093/eurheartj/ehl527 [doi]
PST - ppublish
SO  - Eur Heart J. 2007 Mar;28(5):560-8. doi: 10.1093/eurheartj/ehl527. Epub 2007 Feb 
      21.