PMID- 17314187
OWN - NLM
STAT- MEDLINE
DCOM- 20070928
LR  - 20181113
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Print)
IS  - 0022-3050 (Linking)
VI  - 78
IP  - 9
DP  - 2007 Sep
TI  - CSF neurofilament proteins in the differential diagnosis of dementia.
PG  - 936-8
AB  - BACKGROUND: Neurofilament (NF) proteins are major cytoskeletal constituents of 
      neurons. Increased CSF NF levels may reflect neuronal degeneration. OBJECTIVE: To 
      investigate the diagnostic value of CSF NF analysis to discriminate in relatively 
      young dementia patients between frontotemporal lobe degeneration (FTLD) and early 
      onset Alzheimer's disease (EAD; onset < or = 65 years of age), and in elderly 
      dementia patients between dementia with Lewy bodies (DLB) and late onset AD (LAD; 
      onset > 65 years of age). METHODS: In CSF of 28 FTLD, 37 EAD, 18 DLB and 33 LAD 
      patients, and 26 control subjects, we analysed NF light chain (NFL), 
      phosphorylated NF heavy chain (pNFH), amyloid beta42 protein (Abeta42), total tau 
      and tau phosphorylated at threonine 181 (p-tau181). RESULTS: CSF NFL levels were 
      higher in FTLD patients compared with EAD patients (p<0.001), and diagnostic 
      accuracy of p-tau181 and Abeta42 analysis improved with addition of NFL analysis 
      (sensitivity 86%, specificity 100%). CSF pNFH levels were elevated in DLB, LAD 
      and FTLD compared with controls (p<0.05) but no significant differences were 
      found between the dementia groups. CONCLUSIONS: In the diagnostic workup of 
      relatively young dementia patients, CSF NFL levels may play a role in the 
      discrimination between FTLD and EAD, especially in combination with Abeta42 and 
      p-tau181 analysis.
FAU - de Jong, D
AU  - de Jong D
AD  - Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB, 
      Nijmegen, The Netherlands.
FAU - Jansen, R W M M
AU  - Jansen RW
FAU - Pijnenburg, Y A L
AU  - Pijnenburg YA
FAU - van Geel, W J A
AU  - van Geel WJ
FAU - Borm, G F
AU  - Borm GF
FAU - Kremer, H P H
AU  - Kremer HP
FAU - Verbeek, M M
AU  - Verbeek MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070221
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (MAPT protein, human)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*cerebrospinal fluid/diagnosis
MH  - Amyloid beta-Peptides/cerebrospinal fluid
MH  - Case-Control Studies
MH  - Dementia/*cerebrospinal fluid/diagnosis
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Lewy Body Disease/*cerebrospinal fluid/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Neurofilament Proteins/*cerebrospinal fluid
MH  - Predictive Value of Tests
MH  - tau Proteins/cerebrospinal fluid
PMC - PMC2117885
COIS- Competing interests: None.
EDAT- 2007/02/23 09:00
MHDA- 2007/09/29 09:00
PMCR- 2010/09/01
CRDT- 2007/02/23 09:00
PHST- 2007/02/23 09:00 [pubmed]
PHST- 2007/09/29 09:00 [medline]
PHST- 2007/02/23 09:00 [entrez]
PHST- 2010/09/01 00:00 [pmc-release]
AID - jnnp.2006.107326 [pii]
AID - jn107326 [pii]
AID - 10.1136/jnnp.2006.107326 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):936-8. doi: 
      10.1136/jnnp.2006.107326. Epub 2007 Feb 21.