PMID- 17314259
OWN - NLM
STAT- MEDLINE
DCOM- 20070327
LR  - 20170214
IS  - 0022-0345 (Print)
IS  - 0022-0345 (Linking)
VI  - 86
IP  - 3
DP  - 2007 Mar
TI  - Submandibular glands contribute to increases in plasma BDNF levels.
PG  - 260-4
AB  - Brain-derived neurotrophic factor (BDNF) promotes survival and differentiation of 
      neural cells in the central and peripheral nervous systems. BDNF has been 
      detected in plasma, but its source has not yet been established. Expression of 
      BDNF mRNA has been identified in the submandibular glands when male rats are 
      exposed to acute immobilization stress. In the present study, we investigated 
      whether plasma BDNF is influenced by the submandibular glands in this model. 
      Acute immobilization stress for 60 min significantly increased the level of 
      plasma BDNF. However, plasma BDNF elevation was markedly suppressed in 
      bilaterally sialoadenectomized rats. There were no significant differences 
      between stressed (60 min) and non-stressed rats with respect to the BDNF mRNA 
      expression in the hippocampus, heart, lung, liver, pancreas, or spleen, as 
      determined by real-time polymerase chain-reaction. These findings suggest that 
      the submandibular glands may be the primary source of plasma BDNF in conditions 
      of acute immobilization stress.
FAU - Tsukinoki, K
AU  - Tsukinoki K
AD  - Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa 
      Dental College, Yokosuka, Kanagawa, Japan. ktsukino@kdcnet.ac.jp
FAU - Saruta, J
AU  - Saruta J
FAU - Muto, N
AU  - Muto N
FAU - Sasaguri, K
AU  - Sasaguri K
FAU - Sato, S
AU  - Sato S
FAU - Tan-Ishii, N
AU  - Tan-Ishii N
FAU - Watanabe, Y
AU  - Watanabe Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/*blood
MH  - Immobilization
MH  - Male
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Physiological/*blood
MH  - Submandibular Gland/*metabolism/physiology
EDAT- 2007/02/23 09:00
MHDA- 2007/03/28 09:00
CRDT- 2007/02/23 09:00
PHST- 2007/02/23 09:00 [pubmed]
PHST- 2007/03/28 09:00 [medline]
PHST- 2007/02/23 09:00 [entrez]
AID - 86/3/260 [pii]
AID - 10.1177/154405910708600312 [doi]
PST - ppublish
SO  - J Dent Res. 2007 Mar;86(3):260-4. doi: 10.1177/154405910708600312.