PMID- 1731457
OWN - NLM
STAT- MEDLINE
DCOM- 19920214
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 69
IP  - 3
DP  - 1992 Jan 15
TI  - Comparison between thallium-201 and technetium-99m methoxyisobutyl isonitrile 
      defect size in single-photon emission computed tomography at rest, exercise and 
      redistribution in coronary artery disease.
PG  - 183-7
AB  - Defect size on myocardial tomograms was measured in 30 patients who underwent 2 
      separate studies, 1 with thallium-201 (TI-201), the other with 
      technetium-99m-methoxyisobutyl isonitrile (MIBI). A group of 15 patients with 
      myocardial infarction was studied at rest and received both tracers on the same 
      day. The other 15 patients had documented coronary artery disease. They were were 
      given injections of TI-201 at peak exercise and underwent imaging immediately 
      after exercise and again 4 hours later. They then received a dose of MIBI for 
      imaging at rest. A week later they underwent a second exercise test with the same 
      work load and received a second dose of MIBI. Defect size on single-photon 
      emission computed tomographic images was measured and repeated twice. Results 
      were expressed in percentage of the volume of the whole myocardium. 
      Reproducibility of the defect size measurement was high for TI-201 (r = 0.978; 
      SEE = 1.59) as well as for MIBI (r = 0.981; SEE = 0.80). In patients with 
      coronary artery disease the mean size of the defects was significantly larger 
      with TI-201 than with MIBI at exercise (6.7 +/- 5.2 vs 4.6 +/- 5.2%, 
      respectively, p less than 0.05) and at redistribution (5.1 +/- 4.4 vs 2.8 +/- 
      3.2%, respectively, p less than 0.05), where no difference was seen in patients 
      with myocardial infarction studied only at rest (11.2 +/- 10.4 vs 12.0 +/- 11.5%, 
      respectively, p = not significant). Smaller MIBI defect sizes, when compared with 
      TI-201, in the exercise and redistribution studies were not due to technical 
      artefacts since there was no difference when they were compared at rest.
FAU - Maublant, J C
AU  - Maublant JC
AD  - Department of Nuclear Medicine, Centre Jean Perrin, Clermont, France.
FAU - Marcaggi, X
AU  - Marcaggi X
FAU - Lusson, J R
AU  - Lusson JR
FAU - Boire, J Y
AU  - Boire JY
FAU - Cauvin, J C
AU  - Cauvin JC
FAU - Jacob, P
AU  - Jacob P
FAU - Veyre, A
AU  - Veyre A
FAU - Cassagnes, J
AU  - Cassagnes J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Contrast Media)
RN  - 0 (Nitriles)
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Thallium Radioisotopes)
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Contrast Media
MH  - Coronary Disease/*diagnostic imaging
MH  - Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nitriles
MH  - *Organotechnetium Compounds
MH  - Regression Analysis
MH  - Reproducibility of Results
MH  - Rest
MH  - Technetium Tc 99m Sestamibi
MH  - *Thallium Radioisotopes
MH  - *Tomography, Emission-Computed, Single-Photon
EDAT- 1992/01/15 00:00
MHDA- 1992/01/15 00:01
CRDT- 1992/01/15 00:00
PHST- 1992/01/15 00:00 [pubmed]
PHST- 1992/01/15 00:01 [medline]
PHST- 1992/01/15 00:00 [entrez]
AID - 0002-9149(92)91302-K [pii]
AID - 10.1016/0002-9149(92)91302-k [doi]
PST - ppublish
SO  - Am J Cardiol. 1992 Jan 15;69(3):183-7. doi: 10.1016/0002-9149(92)91302-k.