PMID- 17317133
OWN - NLM
STAT- MEDLINE
DCOM- 20070911
LR  - 20131121
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 101
IP  - 7
DP  - 2007 Jul
TI  - Platelet and plasma BDNF in lower respiratory tract infections of the adult.
PG  - 1493-9
AB  - Enhanced bronchial responsiveness during and following lower respiratory tract 
      infections is a major clinical problem, but its pathogenesis is poorly 
      understood. Brain-derived neurotrophic factor (BDNF), which can be released by 
      platelets and leukocytes, has been identified as a mediator of bronchial 
      hyperresponsiveness. It is unknown whether the release of BDNF is altered during 
      lower respiratory tract infections of the adult. In this clinical pilot study, 16 
      patients (35-80 years old) with the diagnosis of an acute bacterial lower 
      respiratory tract infection and elevated serum concentrations of c-reactive 
      protein (>100 microg/ml) and procalcitonin (>0.1 ng/ml) were examined on 
      admission to the hospital and 1 week after antibiotic treatment. Sixteen age- and 
      sex-matched controls were examined in the same time period. BDNF concentrations 
      in serum and platelets, but not in plasma, were markedly reduced in patients on 
      the day of admission (median <25% of the controls). Analysis of the platelet 
      marker serotonin (5-HT) suggested that the decrease of platelet BDNF is part of a 
      non-specific release of platelet-derived mediators in this condition. Clinical 
      improvement was accompanied by a restoration of serum and platelet BDNF 
      concentrations which returned to control levels after 1 week of treatment. Cell 
      culture experiments revealed that bacterial lipopolysaccharide (LPS) enhanced the 
      release of BDNF by peripheral blood mononuclear cells of the patients at both 
      time points. In conclusion, these data suggest that lower respiratory tract 
      infections might be associated with an augmented release of BDNF by platelets and 
      mononuclear cells.
FAU - Lommatzsch, Marek
AU  - Lommatzsch M
AD  - Department of Pneumology, University of Rostock, 18057 Rostock, Germany. 
      marek.lommatzsch@med.uni-rostock.de
FAU - Niewerth, Anke
AU  - Niewerth A
FAU - Klotz, Jens
AU  - Klotz J
FAU - Schulte-Herbruggen, Olaf
AU  - Schulte-Herbruggen O
FAU - Zingler, Christiana
AU  - Zingler C
FAU - Schuff-Werner, Peter
AU  - Schuff-Werner P
FAU - Virchow, J Christian
AU  - Virchow JC
LA  - eng
PT  - Journal Article
DEP - 20070220
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Blood Platelets/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Leukocytes, Mononuclear/metabolism
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Pneumonia, Bacterial/blood/drug therapy
MH  - Respiratory Tract Infections/*blood/drug therapy
MH  - Serotonin/blood
MH  - Serum/metabolism
EDAT- 2007/02/24 09:00
MHDA- 2007/09/12 09:00
CRDT- 2007/02/24 09:00
PHST- 2006/10/05 00:00 [received]
PHST- 2007/01/03 00:00 [revised]
PHST- 2007/01/09 00:00 [accepted]
PHST- 2007/02/24 09:00 [pubmed]
PHST- 2007/09/12 09:00 [medline]
PHST- 2007/02/24 09:00 [entrez]
AID - S0954-6111(07)00007-8 [pii]
AID - 10.1016/j.rmed.2007.01.003 [doi]
PST - ppublish
SO  - Respir Med. 2007 Jul;101(7):1493-9. doi: 10.1016/j.rmed.2007.01.003. Epub 2007 
      Feb 20.