PMID- 17318955
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20131121
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 11
IP  - 1
DP  - 2006 Jan-Mar
TI  - Are the perioperative changes of serum magnesium in lung surgery arrhythmiogenic?
PG  - 69-73
AB  - PURPOSE: To prospectively study the perioperative changes in serum magnesium 
      (sMg) after major lung resections and their effect to the generation of cardiac 
      dysrhythmias, and to present a brief review of the literature surrounding this 
      phenomenon. PATIENTS AND METHODS: We studied 33 patients with non small cell lung 
      cancer (NSCLC), scheduled for major pulmonary resection. Three patients were 
      excluded from the study due to preoperative medication with beta-blocker and 
      calcium (Ca) antagonists. Pneumonectomy was performed in 10 patients and 
      lobectomy in 20. Heparinized arterial blood samples for the assessment of sMg, 
      potassium (K) and Ca concentration were obtained before surgery, on arrival to 
      the High Dependency Unit (HDU), and on the morning of the first and the second 
      postoperative day. No patient had evidence of cardiac disease. RESULTS: Atrial 
      fibrillation occurred in 3 (10%) patients. There was no statistically significant 
      association between sMg and dysrhythmias. A statistically significant difference 
      after adjusting for age was found between sMg concentration, just after the 
      operation and the first post-operative day and the baseline measurement (before 
      the operation). The type of surgical procedure was not found to be associated 
      with the sMg concentration or the appearance of dysrhythmia. The serum K and Ca 
      concentration for all samples was within normal range. CONCLUSION: Serum 
      concentration of Mg decreases significantly within the first 24 hours of major 
      lung resection. Although our study didn't demonstrate a relationship between 
      decreases in sMg and the generation of arrhythmias, this link is well established 
      in other fields and thus we support the prophylactic MgSO(4) administration in 
      their prevention in such cases whilst we await further larger studies.
FAU - Kotoulas, C
AU  - Kotoulas C
AD  - Department of Cardiothoracic Surgery, Manchester Royal Infirmary, Manchester, UK. 
      chrkotoulas@hol.gr
FAU - Konstantinou, G
AU  - Konstantinou G
FAU - Kostikas, K
AU  - Kostikas K
FAU - Doris, M
AU  - Doris M
FAU - Konstantinou, M
AU  - Konstantinou M
FAU - Prendergast, B
AU  - Prendergast B
FAU - Bouros, D
AU  - Bouros D
FAU - Lioulias, A
AU  - Lioulias A
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/blood/*surgery
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/blood/*surgery
MH  - Magnesium/*blood
MH  - Magnesium Deficiency/*complications
MH  - Male
MH  - Middle Aged
MH  - Pneumonectomy/methods
MH  - *Postoperative Complications
MH  - Prognosis
MH  - Prospective Studies
MH  - Tachycardia, Supraventricular/*etiology
EDAT- 2007/02/24 09:00
MHDA- 2007/03/30 09:00
CRDT- 2007/02/24 09:00
PHST- 2007/02/24 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2007/02/24 09:00 [entrez]
PST - ppublish
SO  - J BUON. 2006 Jan-Mar;11(1):69-73.