PMID- 17318966
OWN - NLM
STAT- MEDLINE
DCOM- 20070424
LR  - 20071115
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 11
IP  - 2
DP  - 2006 Apr-Jun
TI  - Total body irradiation prior to bone marrow transplantation--the experience of 
      the Institute of Oncology Prof. Dr. Al. Trestioreanu Bucharest.
PG  - 167-74
AB  - PURPOSE: To present the technique of total body irradiation (TBI), applied for 
      the first time in Romania, at the Institute of Oncology Bucharest, as part of 
      stem cell transplantation for hematological malignancies. PATIENTS AND METHODS: 
      The total dose administered was 12 Gy at the reference point, 2 Gy/fraction, one 
      fraction per day, 6 consecutive days, with a total dose of 8 - 11.4 Gy delivered 
      to the lung, using Mevatron Primus linear accelerator (6 MV & 15 MV, 200-300 
      cGy/min in isocenter), in vivo dosimetry detectors and equipment for the 
      reference dosimetry, personalized blocks for lung shielding sustained by 
      polymethylmethaacrylate (PPMA) plate, Simulix HP simulator, and computer 
      tomographic (CT) scans. Techniques used were: a) two parallel opposed 
      anteroposterior / posteroanterior (AP/PA) fields with the patient in prone and 
      supine position; b) two parallel opposed lateral fields with the patient placed 
      on a lateral table, at 320 cm from the source. The percentage depth dose, tissue 
      maximum ratio (TMR), off axis ratio (OAR) and the reference dose rate were 
      measured for every patient's geometrical characteristics, with an uncertainty of 
      +/- 2.2% and were used to calculate monitor units and to evaluate the dose in 
      organs at risk (lungs, gonads, eyes etc). RESULTS: 5 patients (3 with the AP/PA 
      technique and 2 with the lateral technique) were irradiated. All patients 
      completed their irradiation in good clinical condition. The acute side effects 
      were minimal (WHO grade 1: nausea/ vomiting--all patients; diarrhea--1 patient; 
      headache--2 patients; photophobia and diplopia--1 patient; head and neck skin 
      erythema--all patients). Because of the short follow-up period no safe evaluation 
      of late side effects can be done. However, during this period one patient 
      developed a non-aggressive form of chronic liver graft vs. host disease (GVHD) 
      and one patient died due to acute GVHD. CONCLUSION: TBI as part of stem cell 
      transplantation for hematological malignancies was successfully realized at our 
      Institute, with favorable clinical results. This technique is easy to carry out 
      and reproducible.
FAU - Anghel, R
AU  - Anghel R
AD  - University of Medicine and Pharmacy Carol Davila, Bucharest, Romania. 
      ranghel@iob.ro
FAU - Matache, G
AU  - Matache G
FAU - Vasile, M
AU  - Vasile M
FAU - Matache, R I
AU  - Matache RI
FAU - Oprea, L
AU  - Oprea L
FAU - Popa, R
AU  - Popa R
FAU - Sucitu, A
AU  - Sucitu A
FAU - Costandache, N
AU  - Costandache N
FAU - Barbulescu, I
AU  - Barbulescu I
FAU - Colita, D
AU  - Colita D
FAU - Varady, Z
AU  - Varady Z
FAU - Tanase, A
AU  - Tanase A
FAU - Moicean, A
AU  - Moicean A
FAU - Arion, C
AU  - Arion C
FAU - Colita, A
AU  - Colita A
FAU - Dumitrache, L
AU  - Dumitrache L
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Leukemia, Myelomonocytic, Acute/drug therapy/radiotherapy/*therapy
MH  - Lymphoma, Non-Hodgkin/drug therapy/radiotherapy/*therapy
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/radiotherapy/*therapy
MH  - Stem Cell Transplantation/*methods
MH  - Whole-Body Irradiation/*methods
EDAT- 2007/02/24 09:00
MHDA- 2007/04/25 09:00
CRDT- 2007/02/24 09:00
PHST- 2007/02/24 09:00 [pubmed]
PHST- 2007/04/25 09:00 [medline]
PHST- 2007/02/24 09:00 [entrez]
PST - ppublish
SO  - J BUON. 2006 Apr-Jun;11(2):167-74.