PMID- 17320080
OWN - NLM
STAT- MEDLINE
DCOM- 20070626
LR  - 20181113
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 204
IP  - 2
DP  - 2007 Apr
TI  - Neurotrophin ligand-receptor systems in somatosensory cortex of adult rat are 
      affected by repeated episodes of ethanol.
PG  - 680-92
AB  - Ethanol exposure profoundly affects learning and memory and neural plasticity. 
      Key players underlying these functions are neurotrophins. The present study 
      explored the effects of ethanol on the distribution of neurotrophins in the 
      cerebral cortex of the adult rat. Age- and weight-matched pairs of adult male, 
      Long-Evans rats were fed a liquid, ethanol-containing (6.7% v/v) diet or pair-fed 
      an isocaloric control diet three consecutive days per week for 6, 12, 18, or 24 
      weeks. Brains were processed immunohistochemically for nerve growth factor (NGF) 
      and brain-derived neurotrophic factor (BDNF) expression and for the expression of 
      three neurotrophin receptors, p75, trkA, and trkB. Total numbers of immunolabeled 
      neurons in specific layers of somatosensory cortex of ethanol- and control-fed 
      animals were determined stereologically. Ethanol exposure induced an increase in 
      the numbers of NGF- or BDNF-expressing neurons and in neurotrophin content per 
      somata. These changes were (a) time and (b) laminar dependent. In contrast, the 
      number of receptor-expressing neurons did not change due to ethanol exposure or 
      to length of time on the ethanol diet. Thus, ethanol induces the recruitment of 
      cortical neurons to express neurotrophins and an increase in the amount of 
      neurotrophin expression per neuron.
FAU - Bruns, Marla B
AU  - Bruns MB
AD  - Department of Neuroscience and Physiology, State University of New York-Upstate 
      Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
FAU - Miller, Michael W
AU  - Miller MW
LA  - eng
GR  - F30 AA015245/AA/NIAAA NIH HHS/United States
GR  - R01 AA007568/AA/NIAAA NIH HHS/United States
GR  - AA 06916/AA/NIAAA NIH HHS/United States
GR  - R01 AA006916/AA/NIAAA NIH HHS/United States
GR  - R37 AA007568/AA/NIAAA NIH HHS/United States
GR  - AA 15245/AA/NIAAA NIH HHS/United States
GR  - AA 07568/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070108
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 3K9958V90M (Ethanol)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Animals
MH  - Central Nervous System Depressants/*pharmacology
MH  - Ethanol/*pharmacology
MH  - Male
MH  - Nerve Growth Factors/*metabolism
MH  - Phosphopyruvate Hydratase/metabolism
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, Nerve Growth Factor/*metabolism
MH  - Somatosensory Cortex/*drug effects
MH  - Time Factors
PMC - PMC1995597
MID - NIHMS21542
EDAT- 2007/02/27 09:00
MHDA- 2007/06/27 09:00
PMCR- 2008/04/01
CRDT- 2007/02/27 09:00
PHST- 2006/10/30 00:00 [received]
PHST- 2006/12/19 00:00 [revised]
PHST- 2006/12/28 00:00 [accepted]
PHST- 2007/02/27 09:00 [pubmed]
PHST- 2007/06/27 09:00 [medline]
PHST- 2007/02/27 09:00 [entrez]
PHST- 2008/04/01 00:00 [pmc-release]
AID - S0014-4886(07)00002-7 [pii]
AID - 10.1016/j.expneurol.2006.12.022 [doi]
PST - ppublish
SO  - Exp Neurol. 2007 Apr;204(2):680-92. doi: 10.1016/j.expneurol.2006.12.022. Epub 
      2007 Jan 8.