PMID- 17320282
OWN - NLM
STAT- MEDLINE
DCOM- 20070604
LR  - 20151119
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 249
IP  - 1
DP  - 2007 Apr 28
TI  - Discovery of cancer biomarkers through the use of mouse models.
PG  - 40-8
AB  - Although our understanding of the molecular pathogenesis of common types of 
      cancer has improved considerably, the development of effective strategies for 
      cancer diagnosis and treatment have lagged behind. Mouse models of cancer 
      potentially represent an efficient means for uncovering diagnostic markers as 
      genetic alterations associated with human tumors can be engineered in mice. In 
      addition, defined stages of tumor development, breeding conditions, and blood 
      sampling can all be controlled and standardized to limit heterogeneity. 
      Alternatively human cancer cells can be injected into mice and tumor development 
      monitored in xenotransplants. Mouse-based studies promise to elucidate a 
      repertoire of protein changes that occur in blood and biological fluids during 
      tumor development. This is illustrated in a study in which we have applied a 
      three-dimensional intact protein analysis system (IPAS) to elucidate detectable 
      protein changes in serum from immunodeficient mice with lung xenografts from 
      orthotopically implanted human A549 lung adenocarcinoma cells. With sufficiently 
      detailed protein sequence identifications, the observed protein changes can be 
      attributed to either the host mouse or the human tumor cells. It is noteworthy 
      that the majority of increases identified have corresponded to relatively 
      abundant serum proteins, some of which have previously been reported as increased 
      in the sera of cancer patients. Proteomic studies of mouse models of cancer allow 
      assessment of the range of changes in plasma proteins that occur with tumor 
      development and may lead to the identification of potential cancer markers 
      applicable to humans.
FAU - Kuick, Rork
AU  - Kuick R
AD  - Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI, 
      USA.
FAU - Misek, David E
AU  - Misek DE
FAU - Monsma, David J
AU  - Monsma DJ
FAU - Webb, Craig P
AU  - Webb CP
FAU - Wang, Hong
AU  - Wang H
FAU - Peterson, Kelli J
AU  - Peterson KJ
FAU - Pisano, Michael
AU  - Pisano M
FAU - Omenn, Gilbert S
AU  - Omenn GS
FAU - Hanash, Samir M
AU  - Hanash SM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070222
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - *Biomarkers, Tumor
MH  - *Disease Models, Animal
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Mice
MH  - Neoplasm Proteins/metabolism
MH  - Neoplasm Transplantation
MH  - Neoplasms/*metabolism
MH  - Proteomics
MH  - RNA, Messenger/metabolism
RF  - 17
EDAT- 2007/02/27 09:00
MHDA- 2007/06/05 09:00
CRDT- 2007/02/27 09:00
PHST- 2006/12/14 00:00 [received]
PHST- 2006/12/14 00:00 [accepted]
PHST- 2007/02/27 09:00 [pubmed]
PHST- 2007/06/05 09:00 [medline]
PHST- 2007/02/27 09:00 [entrez]
AID - S0304-3835(06)00700-2 [pii]
AID - 10.1016/j.canlet.2006.12.032 [doi]
PST - ppublish
SO  - Cancer Lett. 2007 Apr 28;249(1):40-8. doi: 10.1016/j.canlet.2006.12.032. Epub 
      2007 Feb 22.