PMID- 17320293
OWN - NLM
STAT- MEDLINE
DCOM- 20070718
LR  - 20131121
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 146
IP  - 1
DP  - 2007 Apr 25
TI  - Nucleus accumbens opioid signaling conditions short-term flavor preferences.
PG  - 19-30
AB  - Opioid signaling in the nucleus accumbens (NAcc) strongly modulates flavor-based 
      food choice. To further investigate the role of opioid signaling in taste reward, 
      we used a sensory specific satiety (SSS) paradigm to devalue specific flavors of 
      nutritionally identical food pellets in rats. In the NAcc, infusion of a mu 
      opioid (MOP) receptor selective agonist selectively increased consumption of a 
      pre-fed flavor, thus reversing the SSS effect. Conversely, blockade of endogenous 
      opioid signaling with the opioid antagonist naltrexone selectively decreased 
      consumption of a recently consumed flavor, potentiating the SSS effect. No 
      enhancement of consumption was observed if a delay of 3 h was imposed following 
      the intra-NAcc MOP agonist indicating that there were no long-term changes in 
      flavor preference. If a delay was introduced between the initial flavor exposure 
      and the intra-NAcc MOP agonist infusion, pellet consumption was increased 
      non-selectively (irrespective of flavor) suggesting that close temporal 
      contiguity between flavor experience and NAcc opioid action is critical for the 
      opioid effect on flavor preference. In contrast to opioid effects, inactivating 
      NAcc neurons by local microinjection of muscimol (a GABAA agonist) increased 
      consumption of both the pre-fed and non-pre-fed flavors equally. These results 
      demonstrate that opioids released in the NAcc during consumption of palatable 
      foods produce a selective and transient increase in preference for a recently 
      sampled flavor.
FAU - Woolley, J D
AU  - Woolley JD
AD  - The Ernest Gallo Clinic & Research Center, Department of Neurology, University of 
      California, San Francisco, San Francisco, CA 94143, USA. jwoolley@memory.ucsf.edu
FAU - Lee, B S
AU  - Lee BS
FAU - Taha, S A
AU  - Taha SA
FAU - Fields, H L
AU  - Fields HL
LA  - eng
PT  - Journal Article
DEP - 20070221
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Analgesics, Opioid)
RN  - 0 (GABA Agonists)
RN  - 0 (Narcotic Antagonists)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 2763-96-4 (Muscimol)
RN  - 5S6W795CQM (Naltrexone)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Analgesics, Opioid/*metabolism/pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal
MH  - Conditioning, Operant/*physiology
MH  - Eating/drug effects
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology
MH  - Food Preferences/drug effects/*physiology
MH  - GABA Agonists/pharmacology
MH  - Male
MH  - Morphine/pharmacology
MH  - Muscimol/pharmacology
MH  - Naltrexone/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Nucleus Accumbens/drug effects/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Signal Transduction/drug effects/*physiology
MH  - Taste/*physiology
MH  - Time Factors
EDAT- 2007/02/27 09:00
MHDA- 2007/07/19 09:00
CRDT- 2007/02/27 09:00
PHST- 2006/10/29 00:00 [received]
PHST- 2007/01/03 00:00 [revised]
PHST- 2007/01/08 00:00 [accepted]
PHST- 2007/02/27 09:00 [pubmed]
PHST- 2007/07/19 09:00 [medline]
PHST- 2007/02/27 09:00 [entrez]
AID - S0306-4522(07)00054-1 [pii]
AID - 10.1016/j.neuroscience.2007.01.005 [doi]
PST - ppublish
SO  - Neuroscience. 2007 Apr 25;146(1):19-30. doi: 10.1016/j.neuroscience.2007.01.005. 
      Epub 2007 Feb 21.