PMID- 17321339
OWN - NLM
STAT- MEDLINE
DCOM- 20070330
LR  - 20121003
IS  - 0741-5214 (Print)
IS  - 0741-5214 (Linking)
VI  - 45
IP  - 3
DP  - 2007 Mar
TI  - The role of human leukocyte antigen genes in the formation of abdominal aortic 
      aneurysms.
PG  - 475-80
AB  - BACKGROUND: Increasing evidence suggests an autoimmune component to abdominal 
      aortic aneurysm (AAA) formation. This study was conducted to determine if a 
      difference exists in human leukocyte antigen (HLA) allele distribution between 
      patients with AAA and population controls, and between patients with small and 
      large AAA. METHODS: Patients with known AAA attending the vascular unit were 
      consented for recruitment. HLA-A, HLA-B and HLA-DR was determined by polymerase 
      chain reaction and sequence-specific oligonucleotide probes. The distribution of 
      these alleles in the Northern Ireland general population was obtained from the 
      histocompatibility and immunogenetics database. The chi(2) test was used for 
      statistical analysis with Bonferroni correction. RESULTS: A total of 241 AAA 
      patients were recruited, with a wide range of aneurysm size. In class I, the most 
      frequent allele families were HLA-A*02 and *01 and HLA-B*07, *08, and *44. In 
      class II, HLA-DRB1*03, *04, *07, and *15 were the most frequent. HLA-A*11 was 
      lower in AAA cases (10.4% vs 15.0%; P = .08), whereas HLA-B*08 was lower in the 
      controls (29.8% vs 36.5%; P = .05) and HLA-DRB1*11 was lower in cases (4.2% vs 
      8.1%; P = .05). After Bonferroni correction, however, the proportion of allele 
      families was not significantly different in AAA patients compared with the 
      proportion seen in controls. HLA-DRB1*11 and *14 had a lower prevalence in large 
      AAAs (0.9% vs 6.7% [P = .05]; 0.0% vs 5.9% [P = .03]). HLA-A*68 was also lower in 
      large AAA (1.9% vs 11.9%; P = .0075). After Bonferroni correction, however, no 
      difference was demonstrated between small and large aneurysms. CONCLUSION: This 
      study provides more definitive results on this important subject and has failed 
      to demonstrate the risk association between AAA and these alleles as reported by 
      others. Therefore, the role of these particular genes and the autoimmune 
      component in AAA etiology does not appear to be as crucial as previously 
      proposed.
FAU - Badger, Stephen A
AU  - Badger SA
AD  - Vascular and Endovascular Surgery Centre, Belfast City Hospital, Belfast, United 
      Kingdom. Stephen@Badger.tc
FAU - Soong, Chee V
AU  - Soong CV
FAU - O'Donnell, Mark E
AU  - O'Donnell ME
FAU - Middleton, Derek
AU  - Middleton D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Aneurysm, Abdominal/*genetics/pathology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Northern Ireland
MH  - Phenotype
MH  - Risk Factors
EDAT- 2007/02/27 09:00
MHDA- 2007/03/31 09:00
CRDT- 2007/02/27 09:00
PHST- 2006/07/21 00:00 [received]
PHST- 2006/09/19 00:00 [accepted]
PHST- 2007/02/27 09:00 [pubmed]
PHST- 2007/03/31 09:00 [medline]
PHST- 2007/02/27 09:00 [entrez]
AID - S0741-5214(07)00021-3 [pii]
AID - 10.1016/j.jvs.2006.09.067 [doi]
PST - ppublish
SO  - J Vasc Surg. 2007 Mar;45(3):475-80. doi: 10.1016/j.jvs.2006.09.067.