PMID- 17321783
OWN - NLM
STAT- MEDLINE
DCOM- 20070516
LR  - 20081121
IS  - 1359-6101 (Print)
IS  - 1359-6101 (Linking)
VI  - 18
IP  - 1-2
DP  - 2007 Feb-Apr
TI  - Interplay of pathogens, cytokines and other stress signals in the regulation of 
      dendritic cell function.
PG  - 5-17
AB  - Dendritic cells (DCs) are the only antigen-presenting cell capable of activating 
      naive T lymphocytes, and hence they play a crucial role in the induction of 
      adaptive immunity. Immature DCs sample and process antigens, and efficiently 
      sense a large variety of signals from the surrounding environment. Upon 
      activation, they become capable to activate naive T cells and to direct the 
      differentiation and polarization of effector T lymphocytes. It is becoming 
      increasingly clear that different signals are able to determine distinct programs 
      of DC differentiation and different forms of immunity and tolerance. In the past 
      few years many advances have been made in addressing the action exerted by 
      pathogen-associated molecular patterns (PAMPs), cytokines, chemokines, and other 
      less characterized stress molecules on the activity of DCs. In this review we 
      focus on the multiplicity of innate signals able to modulate the functional 
      profile of DCs.
FAU - Sabatte, Juan
AU  - Sabatte J
AD  - Institute of Haematological Research, National Academy of Medicine and National 
      Reference Centre for AIDS, Department of Microbiology, Buenos Aires University 
      School of Medicine, Buenos Aires, Argentina.
FAU - Maggini, Julian
AU  - Maggini J
FAU - Nahmod, Karen
AU  - Nahmod K
FAU - Amaral, Maria M
AU  - Amaral MM
FAU - Martinez, Diego
AU  - Martinez D
FAU - Salamone, Gabriela
AU  - Salamone G
FAU - Ceballos, Ana
AU  - Ceballos A
FAU - Giordano, Mirta
AU  - Giordano M
FAU - Vermeulen, Monica
AU  - Vermeulen M
FAU - Geffner, Jorge
AU  - Geffner J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20070226
PL  - England
TA  - Cytokine Growth Factor Rev
JT  - Cytokine & growth factor reviews
JID - 9612306
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Cell Differentiation/*immunology
MH  - Cytokines/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunity, Innate
MH  - Lymphocyte Activation/immunology
MH  - Signal Transduction/*immunology
MH  - Stress, Physiological/immunology
MH  - T-Lymphocytes/immunology
RF  - 159
EDAT- 2007/02/27 09:00
MHDA- 2007/05/17 09:00
CRDT- 2007/02/27 09:00
PHST- 2007/02/27 09:00 [pubmed]
PHST- 2007/05/17 09:00 [medline]
PHST- 2007/02/27 09:00 [entrez]
AID - S1359-6101(07)00003-2 [pii]
AID - 10.1016/j.cytogfr.2007.01.002 [doi]
PST - ppublish
SO  - Cytokine Growth Factor Rev. 2007 Feb-Apr;18(1-2):5-17. doi: 
      10.1016/j.cytogfr.2007.01.002. Epub 2007 Feb 26.