PMID- 17321901
OWN - NLM
STAT- MEDLINE
DCOM- 20070608
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 2
DP  - 2007 Feb
TI  - Allergen-specific IgG1 provides parsimonious heritability estimates for 
      atopy-associated immune responses to allergens.
PG  - 113-21
AB  - Although serum total immunoglobulin E (IgE) is generally elevated in atopic 
      conditions, it is an unreliable trait for dissecting the genetic and 
      environmental components contributing to atopic immune responses, because it can 
      be significantly confounded by demographic factors (age, gender, and race) and 
      clinical status (atopic vs nonatopic). Allergen-specific IgE is a discontinuous 
      trait present only in those with sensitivity to allergens. However, all people 
      will produce allergen-specific immunoglobulin G1 (IgG1), which is elevated among 
      those atopically sensitized to specific allergens. We screened 91 Caucasian 
      nuclear families (N = 367) with medical histories of atopic diseases and used 
      variance components analysis to compare heritability estimates for total IgE and 
      IgG1 produced against the common major allergen from house dust mite 
      Dermatophagoides pteronyssinus (Der p 1). An estimate of total IgE heritability 
      was about 48%, although this was significantly confounded by age, gender, and 
      clinical atopic status. In contrast, Der p 1-IgG1 demonstrated a significant 
      inherited component of about 62% that was not influenced by age, gender, or 
      clinical status. For genetic studies of atopic humoral responses, 
      allergen-specific IgG1 may be a more reliable quantitative trait than serum IgE. 
      Moreover, atopy is an inherited deregulation of immune responses to noninfectious 
      antigens, involving antibody isotypes other than IgE.
FAU - Liebeler, Carol L
AU  - Liebeler CL
AD  - The Asthma and Allergy Program, Department of Medicine, University of Minnesota 
      Medical School, Minneapolis, MN 55455, USA.
FAU - Basu, Saonli
AU  - Basu S
FAU - Jackola, Duaine R
AU  - Jackola DR
LA  - eng
GR  - R01 HL049609/HL/NHLBI NIH HHS/United States
GR  - 2 R01-HL049609-11/HL/NHLBI NIH HHS/United States
GR  - R01 HL049609-14/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20061228
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Arthropod Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.22.- (Dermatophagoides pteronyssinus antigen p 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies/*blood/immunology
MH  - Antibody Specificity
MH  - Antigens, Dermatophagoides/*immunology
MH  - Arthropod Proteins
MH  - Biomarkers/blood
MH  - Cysteine Endopeptidases
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypersensitivity, Immediate/*blood/ethnology/*genetics
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/*blood
MH  - Male
MH  - Middle Aged
MH  - Quantitative Trait, Heritable
MH  - White People
PMC - PMC1868472
MID - NIHMS19562
EDAT- 2007/02/27 09:00
MHDA- 2007/06/09 09:00
PMCR- 2008/02/03
CRDT- 2007/02/27 09:00
PHST- 2006/09/14 00:00 [received]
PHST- 2006/11/27 00:00 [revised]
PHST- 2006/12/01 00:00 [accepted]
PHST- 2007/02/27 09:00 [pubmed]
PHST- 2007/06/09 09:00 [medline]
PHST- 2007/02/27 09:00 [entrez]
PHST- 2008/02/03 00:00 [pmc-release]
AID - S0198-8859(06)00607-0 [pii]
AID - 10.1016/j.humimm.2006.12.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 Feb;68(2):113-21. doi: 10.1016/j.humimm.2006.12.001. Epub 2006 
      Dec 28.