PMID- 17322133
OWN - NLM
STAT- MEDLINE
DCOM- 20070612
LR  - 20220129
IS  - 1064-7481 (Print)
IS  - 1064-7481 (Linking)
VI  - 15
IP  - 3
DP  - 2007 Mar
TI  - Premorbid personality and behavioral and psychological symptoms in probable 
      Alzheimer disease.
PG  - 202-13
AB  - OBJECTIVES: Previous research investigating the influence of premorbid 
      personality on behavioral and psychological symptoms in dementia (BPSD) has 
      produced mixed findings. Addressing some limitations of previous studies, the 
      authors aimed to investigate whether some of the common individual symptoms of 
      BPSD (depression, anxiety, irritability, and aggression) were associated with key 
      aspects of previous personality (neuroticism and agreeableness); and also to 
      perform an exploratory investigation into the broader influence of personality 
      factors on behavioral and psychological syndromes. METHODS: Two hundred eight 
      patients with a diagnosis of probable Alzheimer disease were assessed for the 
      presence of BPSD over the disease course using the caregiver-rated 
      Neuropsychiatric Inventory (NPI). One or two knowledgeable informants rated 
      patients' midlife personalities using a retrospective version of the NEO-FFI 
      questionnaire. RESULTS: Premorbid neuroticism was correlated with anxiety and 
      total NPI score, although not with depression. Premorbid agreeableness was 
      negatively correlated with agitation and irritability. Principal components 
      analysis of the 10 NPI behavioral domains identified three syndromes: 
      "agitation/apathy," "psychosis," and "affect." In stepwise linear regression 
      analyses, including personality domains from the Five-Factor Model and a range of 
      potential confounders as independent variables; the only significant personality 
      predictor of a behavioral syndrome was "agitation/apathy," predicted by lower 
      premorbid agreeableness. CONCLUSION: Lower premorbid agreeableness is associated 
      with agitation and irritability symptoms in Alzheimer disease and also predicts 
      an "agitation/apathy" syndrome. The relationship between premorbid neuroticism 
      and BPSD is less straightforward, and premorbid neuroticism does not appear to be 
      associated with depression in Alzheimer disease or predict an "affect" syndrome.
FAU - Archer, Nicola
AU  - Archer N
AD  - King's College London, MRC Centre for Neurodegeneration Research, Institute of 
      Psychiatry, London, UK. N.Archer@iop.kcl.ac.uk
FAU - Brown, Richard G
AU  - Brown RG
FAU - Reeves, Suzanne J
AU  - Reeves SJ
FAU - Boothby, Harry
AU  - Boothby H
FAU - Nicholas, Helen
AU  - Nicholas H
FAU - Foy, Catherine
AU  - Foy C
FAU - Williams, Julie
AU  - Williams J
FAU - Lovestone, Simon
AU  - Lovestone S
LA  - eng
GR  - G0300429/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American 
      Association for Geriatric Psychiatry
JID - 9309609
SB  - IM
MH  - Affect
MH  - Aged
MH  - Aged, 80 and over
MH  - Aggression
MH  - Alzheimer Disease/complications/diagnosis/*psychology
MH  - Anxiety/complications/psychology
MH  - *Behavior
MH  - Depression/complications/psychology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Irritable Mood
MH  - Male
MH  - Neuropsychological Tests/statistics & numerical data
MH  - Neurotic Disorders/complications/psychology
MH  - *Personality
MH  - Predictive Value of Tests
MH  - Principal Component Analysis/methods
MH  - Psychometrics/methods
MH  - Psychomotor Agitation/complications/psychology
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2007/02/27 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/02/27 09:00
PHST- 2007/02/27 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/02/27 09:00 [entrez]
AID - 15/3/202 [pii]
AID - 10.1097/01.JGP.0000232510.77213.10 [doi]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2007 Mar;15(3):202-13. doi: 
      10.1097/01.JGP.0000232510.77213.10.