PMID- 17324158
OWN - NLM
STAT- MEDLINE
DCOM- 20070821
LR  - 20131121
IS  - 1462-5814 (Print)
IS  - 1462-5814 (Linking)
VI  - 9
IP  - 7
DP  - 2007 Jul
TI  - Transcriptome profile of dendritic cells during malaria: cAMP regulation of IL-6.
PG  - 1738-52
AB  - Dendritic cells (DCs) have been proposed as mediators of immunity against malaria 
      parasites, as well as a target for inhibition of cellular responses. Here we 
      describe the transcriptomic analysis of spleen DCs in response to Plasmodium 
      infection in a rodent model. We identified a high number of unique transcripts 
      modulated in DCs upon infection. Many cellular functions suffer extensive genomic 
      regulation including the cell cycle, the glycolysis and purine metabolism 
      pathways and also defence responses. Only a small fraction of the regulated genes 
      are coincident with the response induced by other pathogens, suggesting that 
      Plasmodium induces a unique genetic re-programming of DCs. We confirmed 
      regulation of a number of cytokines at the mRNA level including IL-6, IL-10 and 
      IFN-gamma. We further dissected a signalling pathway regulating 
      Plasmodium-induced expression of IL-6 by DCs, which is mediated by release of 
      PGE2, increases in intracellular cAMP and activation of PKA and p38-MAPK.
FAU - Carapau, Daniel
AU  - Carapau D
AD  - New York University School of Medicine, Department of Medical Parasitology, 341E. 
      25th St., New York, NY 10010, USA.
FAU - Kruhofer, Mogens
AU  - Kruhofer M
FAU - Chatalbash, Allison
AU  - Chatalbash A
FAU - Orengo, Jamie Marie
AU  - Orengo JM
FAU - Mota, Maria Manuel
AU  - Mota MM
FAU - Rodriguez, Ana
AU  - Rodriguez A
LA  - eng
GR  - R01AI053698/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070223
PL  - India
TA  - Cell Microbiol
JT  - Cellular microbiology
JID - 100883691
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Proteins)
RN  - 0 (Proteome)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - Cyclic AMP/*metabolism
MH  - Cytokines/genetics/*metabolism
MH  - Dendritic Cells/*metabolism
MH  - Erythrocytes/parasitology
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation
MH  - Interleukin-6/genetics/*metabolism
MH  - Malaria/immunology/parasitology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Oligonucleotide Array Sequence Analysis
MH  - Plasmodium yoelii/*pathogenicity
MH  - Proteins/genetics/*metabolism
MH  - Proteome
MH  - *Signal Transduction
MH  - Spleen/cytology/immunology
MH  - Transcription, Genetic
EDAT- 2007/02/28 09:00
MHDA- 2007/08/22 09:00
CRDT- 2007/02/28 09:00
PHST- 2007/02/28 09:00 [pubmed]
PHST- 2007/08/22 09:00 [medline]
PHST- 2007/02/28 09:00 [entrez]
AID - CMI910 [pii]
AID - 10.1111/j.1462-5822.2007.00910.x [doi]
PST - ppublish
SO  - Cell Microbiol. 2007 Jul;9(7):1738-52. doi: 10.1111/j.1462-5822.2007.00910.x. 
      Epub 2007 Feb 23.