PMID- 17324218
OWN - NLM
STAT- MEDLINE
DCOM- 20070925
LR  - 20131121
IS  - 1395-3907 (Print)
IS  - 1395-3907 (Linking)
VI  - 85
IP  - 5
DP  - 2007 Aug
TI  - Intracameral mydriatics in phacoemulsification surgery obviate the need for 
      epinephrine irrigation.
PG  - 546-50
AB  - PURPOSE: To evaluate the possibility of removing epinephrine from the irrigating 
      solution in phacoemulsification surgery when using intracameral mydriatics 
      (ICMs). METHODS: We carried out a prospective, randomized, double-blinded study 
      of 140 patients with age-related cataracts, scheduled for unilateral 
      phacoemulsification. The first part of the study involved 90 patients divided 
      into two groups. Patients in both groups were given 150 microl ICMs at the 
      beginning of the procedure. In group 1, 0.6 microg/ml epinephrine was added to 
      the irrigating balanced salt solution. No epinephrine was added to the irrigation 
      solution used in group 2. The second part of the study involved 50 patients, all 
      of whom were given topical mydriatics (TMs) and then similarly divided into two 
      groups and treated as in the first study setting. RESULTS: With ICMs, pupil sizes 
      generally increased during the procedures. Remarkably, this increase was 
      significantly greater without epinephrine (13 +/- 19% versus 4 +/- 14%; p = 
      0.02). In the TMs setting, pupil sizes decreased intraoperatively in both groups; 
      significantly more without epinephrine (- 5 +/- 4% versus - 12 +/- 7%; p < 
      0.001). CONCLUSIONS: An irrigating solution without epinephrine can safely be 
      used with ICMs. The increase in pupil size during the procedure is greater 
      without epinephrine. This study also confirms earlier findings that epinephrine 
      is beneficial when using TMs.
FAU - Lundberg, Bjorn
AU  - Lundberg B
AD  - Department of Clinical Sciences/Ophthalmology, Umea University Hospital, Umea, 
      Sweden. bjorn.lundberg@ophthal.umu.se
FAU - Behndig, Anders
AU  - Behndig A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20070227
PL  - Denmark
TA  - Acta Ophthalmol Scand
JT  - Acta ophthalmologica Scandinavica
JID - 9507578
RN  - 0 (Mydriatics)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 98PI200987 (Lidocaine)
RN  - I76F4SHP7J (Cyclopentolate)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Aged
MH  - Cyclopentolate/administration & dosage
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Epinephrine/*administration & dosage
MH  - Humans
MH  - Lidocaine/administration & dosage
MH  - Mydriatics/*administration & dosage
MH  - *Phacoemulsification
MH  - Phenylephrine/administration & dosage
MH  - Prospective Studies
MH  - Pupil/drug effects
MH  - Therapeutic Irrigation
EDAT- 2007/02/28 09:00
MHDA- 2007/09/26 09:00
CRDT- 2007/02/28 09:00
PHST- 2007/02/28 09:00 [pubmed]
PHST- 2007/09/26 09:00 [medline]
PHST- 2007/02/28 09:00 [entrez]
AID - AOS892 [pii]
AID - 10.1111/j.1600-0420.2007.00892.x [doi]
PST - ppublish
SO  - Acta Ophthalmol Scand. 2007 Aug;85(5):546-50. doi: 
      10.1111/j.1600-0420.2007.00892.x. Epub 2007 Feb 27.