PMID- 17324541
OWN - NLM
STAT- MEDLINE
DCOM- 20070914
LR  - 20131121
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 112
IP  - 1
DP  - 2007 May 30
TI  - Effects of osthol on blood pressure and lipid metabolism in stroke-prone 
      spontaneously hypertensive rats.
PG  - 26-31
AB  - Osthol, a coumarin compound, was isolated from the dried fruits of Cnidium 
      monnieri (Umbelliferae) and the effect of dietary osthol on hypertension and 
      lipid metabolism was examined in stroke-prone spontaneously hypertensive rats 
      (SHRSP). Six-week-old male SHRSP were fed the experimental diet containing 0.05% 
      osthol by weight for 4 weeks with free access to the diet and water. Elevation of 
      systolic blood pressure was significantly suppressed on and after 3 weeks. In 
      addition, significant decreases in cholesterol and triglyceride contents in the 
      liver were recognized without any significant changes in serum lipids profiles. A 
      comparative study on hepatic mRNA expression indicated that osthol induced a 
      significant increase in 3-hydroxy-3-methylglutaryl coenzymeA (HMG-CoA) reductase 
      mRNA expression, which may lead to decrease in hepatic cholesterol pool through 
      inhibition of the enzyme activity. Moreover, osthol induced a significant 
      increase in acyl-CoA oxidase mRNA expression associated with an increase in 
      carnitine palmitoyl transferase 1a mRNA expression, which suggests the 
      acceleration of beta-oxidation of hepatic fatty acids. This may be responsible, 
      at least in part, for the reduction of hepatic triglyceride content in SHRSP. 
      These beneficial effects of osthol could be useful for both prevention of 
      atherosclerosis and suppression of hepatic lipid accumulation.
FAU - Ogawa, Hiroshi
AU  - Ogawa H
AD  - Department of Hygiene, Kinki University School of Medicine, 377-2 Ohno-Higashi, 
      Osaka-Sayama City, Osaka 589-8511, Japan. ogawa-h@med.kindai.ac.jp
FAU - Sasai, Noriko
AU  - Sasai N
FAU - Kamisako, Toshinori
AU  - Kamisako T
FAU - Baba, Kimiye
AU  - Baba K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070201
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Coumarins)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases)
RN  - XH1TI1759C (osthol)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/*pharmacology
MH  - Blood Pressure/*drug effects
MH  - Cholesterol/metabolism
MH  - *Cnidium
MH  - Coumarins/*pharmacology
MH  - Fruit
MH  - Hydroxymethylglutaryl CoA Reductases/biosynthesis/genetics
MH  - Lipid Metabolism/*drug effects
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Plant Extracts/pharmacology
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Stroke
MH  - Triglycerides/metabolism
EDAT- 2007/02/28 09:00
MHDA- 2007/09/15 09:00
CRDT- 2007/02/28 09:00
PHST- 2006/07/10 00:00 [received]
PHST- 2006/12/19 00:00 [revised]
PHST- 2007/01/25 00:00 [accepted]
PHST- 2007/02/28 09:00 [pubmed]
PHST- 2007/09/15 09:00 [medline]
PHST- 2007/02/28 09:00 [entrez]
AID - S0378-8741(07)00059-1 [pii]
AID - 10.1016/j.jep.2007.01.028 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2007 May 30;112(1):26-31. doi: 10.1016/j.jep.2007.01.028. Epub 
      2007 Feb 1.