PMID- 17325942
OWN - NLM
STAT- MEDLINE
DCOM- 20070522
LR  - 20220311
IS  - 1369-3786 (Print)
IS  - 1369-3786 (Linking)
VI  - 45
IP  - 1
DP  - 2007 Feb
TI  - Generic human leukocyte antigen class II (DRB1 and DQB1) alleles in patients with 
      paracoccidioidomycosis.
PG  - 35-40
AB  - Human leukocyte antigen (HLA) class II alleles are involved in antigen processing 
      and in the presentation of antigens to T lymphocytes. Few studies have 
      investigated HLA genes in paracoccidioidomycosis. In the present investigation, 
      we analyzed the distribution of the HLA class II alleles DRB1 and DQB1 in 45 
      healthy volunteers and in 80 patients with paracoccidioidomycosis. The patients 
      presented with various clinical forms of the disease, and allele distribution was 
      evaluated individually in each presentation type. In patients with the unifocal 
      chronic form of the disease, a mild clinical presentation in which lesions are 
      restricted or localized, the HLA allele most commonly seen was DRB1*11 (p<0.039). 
      This suggests that the participation of HLA antigens may influence the outcome of 
      the host-parasite interaction in paracoccidioidomycosis, regulating the immune 
      response to Paracoccidioides brasiliensis antigens.
FAU - Sadahiro, Aya
AU  - Sadahiro A
AD  - Department of Parasitology, Federal University of Amazonas, Biological Sciences 
      Institute, Manaus, Brazil.
FAU - Roque, Ana C M
AU  - Roque AC
FAU - Shikanai-Yasuda, Maria A
AU  - Shikanai-Yasuda MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Chronic Disease
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioides/*growth & development
MH  - Paracoccidioidomycosis/*genetics/immunology/microbiology
EDAT- 2007/02/28 09:00
MHDA- 2007/05/23 09:00
CRDT- 2007/02/28 09:00
PHST- 2007/02/28 09:00 [pubmed]
PHST- 2007/05/23 09:00 [medline]
PHST- 2007/02/28 09:00 [entrez]
AID - 770213524 [pii]
AID - 10.1080/13693780600999132 [doi]
PST - ppublish
SO  - Med Mycol. 2007 Feb;45(1):35-40. doi: 10.1080/13693780600999132.