PMID- 17326407
OWN - NLM
STAT- MEDLINE
DCOM- 20071011
LR  - 20070228
IS  - 1001-4454 (Print)
IS  - 1001-4454 (Linking)
VI  - 29
IP  - 10
DP  - 2006 Oct
TI  - [The experimental study on bone marrow stem cell transplantition combinated with 
      bushen fang therapy for DMD].
PG  - 1056-8
AB  - OBJECTIVE: To investigate the effect on bone marrow stem cell transplantition 
      (BMST) combinated with Bushen fang therapy in mdx mice. METHODS: Cultured the 
      bone marrow cells of C56BL/6 in vitro and tranplante these cells to mdx mice 
      after irradiation. Bushen fang was used to cure the mdx mice after BMST. The 
      survivel rate, symptom of Graft Versus Host Disease (GVHD) and motor function of 
      model mice following irradiation and transplantation were observed 4 or 8 months 
      after BMST, prepared the freeze-splice of muscles of each group, and made HE 
      staining. The dystrophin (DYS) was detected by SABC immunofluorescene. RESULTS: 
      Bushen fang could decrease the rate of centrally nucleated fibers (CNF), enhance 
      expressional rate of DYS in different level and relieve the symptom of GVHD in 
      transplanted mice. CONCLUSION: Bushen fang can improve the therapeutic efficacy 
      of BMST.
FAU - Lu, Xi-lin
AU  - Lu XL
AD  - Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, 
      Guangzhou 510080, China.
FAU - Li, Qun
AU  - Li Q
FAU - Yao, Xiao-li
AU  - Yao XL
FAU - Zhang, Wei-xi
AU  - Zhang WX
FAU - Zhang, Cheng
AU  - Zhang C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhong Yao Cai
JT  - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
JID - 9426370
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Dystrophin)
SB  - IM
MH  - Animals
MH  - Combined Modality Therapy
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Dystrophin/biosynthesis
MH  - Female
MH  - Graft vs Host Disease/pathology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred mdx
MH  - Muscle, Skeletal/metabolism/pathology
MH  - Muscular Dystrophy, Duchenne/drug therapy/mortality/*therapy
MH  - Phytotherapy
MH  - Plants, Medicinal/chemistry
MH  - Survival Rate
EDAT- 2007/03/01 09:00
MHDA- 2007/10/12 09:00
CRDT- 2007/03/01 09:00
PHST- 2007/03/01 09:00 [pubmed]
PHST- 2007/10/12 09:00 [medline]
PHST- 2007/03/01 09:00 [entrez]
PST - ppublish
SO  - Zhong Yao Cai. 2006 Oct;29(10):1056-8.