PMID- 17327331
OWN - NLM
STAT- MEDLINE
DCOM- 20070427
LR  - 20191210
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 30
IP  - 3
DP  - 2007 Mar
TI  - Association between serum concentrations of persistent organic pollutants and 
      insulin resistance among nondiabetic adults: results from the National Health and 
      Nutrition Examination Survey 1999-2002.
PG  - 622-8
AB  - OBJECTIVE: We reported strong relations between serum concentrations of 
      persistent organic pollutants (POPs), especially organochlorine (OC) pesticides 
      or nondioxin-like polychlorinated biphenyls (PCBs), and prevalence of diabetes in 
      a U.S population with background exposure to POPs. Here, we investigated POPs and 
      insulin resistance, a frequent pathogenic precursor of type 2 diabetes. RESEARCH 
      DESIGN AND METHODS: Serum POPs and homeostasis model assessment of insulin 
      resistance (HOMA-IR) were investigated cross-sectionally in 749 nondiabetic 
      participants aged > or = 20 years. Nineteen POPs in five subclasses were 
      selected, detectable in > or = 60% of participants. RESULTS: Among subclasses, OC 
      pesticides were most strongly associated with HOMA-IR. Adjusted geometric means 
      of HOMA were 3.27, 3.36, 3.48, and 3.85 (P for trend <0.01) across quartiles of 
      OC pesticides. The relationship strengthened with increasing HOMA-IR percentile: 
      adjusted odds ratios comparing the highest versus lowest POPs quartile were 1.8 
      for being > or = 50th percentile of HOMA-IR, 4.4 for being > or = 75th 
      percentile, and 7.5 for being > or = 90th percentile. Associations with elevated 
      HOMA-IR appeared to be specific to oxychlordane and trans-nonachlor but also were 
      found for two nondioxin-like PCBs. No HOMA-IR associations were seen in the other 
      three POP subclasses. The association between OC pesticides and HOMA-IR tended to 
      strengthen as waist circumference increased, with no apparent association in the 
      lowest quartile of OC pesticide concentrations. CONCLUSIONS: These findings, 
      coupled with those concerning diabetes prevalence, suggest that OC pesticides and 
      nondioxin-like PCBs may be associated with type 2 diabetes risk by increasing 
      insulin resistance, and POPs may interact with obesity to increase the risk of 
      type 2 diabetes.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422. lee_dh@knu.ac.kr
FAU - Lee, In-Kyu
AU  - Lee IK
FAU - Jin, Soo-Hee
AU  - Jin SH
FAU - Steffes, Michael
AU  - Steffes M
FAU - Jacobs, David R Jr
AU  - Jacobs DR Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Diabetes Mellitus, Type 2/epidemiology
MH  - Environmental Pollutants/*blood
MH  - *Health Surveys
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - *Insulin Resistance
MH  - Nutrition Surveys
MH  - Odds Ratio
MH  - Polychlorinated Biphenyls/*blood
MH  - United States
EDAT- 2007/03/01 09:00
MHDA- 2007/04/28 09:00
CRDT- 2007/03/01 09:00
PHST- 2007/03/01 09:00 [pubmed]
PHST- 2007/04/28 09:00 [medline]
PHST- 2007/03/01 09:00 [entrez]
AID - 30/3/622 [pii]
AID - 10.2337/dc06-2190 [doi]
PST - ppublish
SO  - Diabetes Care. 2007 Mar;30(3):622-8. doi: 10.2337/dc06-2190.