PMID- 17336530
OWN - NLM
STAT- MEDLINE
DCOM- 20070706
LR  - 20070327
IS  - 0967-5868 (Print)
IS  - 0967-5868 (Linking)
VI  - 14
IP  - 5
DP  - 2007 May
TI  - Inducible heat shock protein 70, interleukin-18, and tumor necrosis factor alpha 
      correlate with outcomes in spontaneous intracerebral hemorrhage.
PG  - 435-41
AB  - Inducible heat shock protein 70 (HSP70), a stress protein detected in the central 
      nervous system, is expressed when a cell or organism is under stress. 
      Interleukin-18 (IL-18) and tumor necrosis factor alpha (TNF-alpha) are 
      multipotential early proinflammatory cytokines. Our objective was to determine 
      protein levels of HSP70, IL-18, and TNF-alpha as well as mRNA levels of HSP70, 
      IL-18, and TNF-alpha in the plasma and CSF of spontaneous intracerebral 
      hemorrhage (ICH) patients, and to correlate these with disease outcome. Serial 
      measurement of the proteins in CSF and plasma and of the mRNAs in peripheral 
      blood mononuclear cells was conducted in 43 patients (mean age, 64+/-9 years; 23 
      men and 20 women). Ten (23%) patients died. We found that the damaged brain 
      releases TNF-alpha and HSP70 to the peripheral blood and that plasma levels of 
      these are highly associated with mortality in spontaneous ICH patients.
FAU - Fang, Hsin-Yuan
AU  - Fang HY
AD  - Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan.
FAU - Ko, Wen-Je
AU  - Ko WJ
FAU - Lin, Ching-Yuang
AU  - Lin CY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070302
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Interleukin-18)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Cerebral Hemorrhage/*metabolism/mortality/radiotherapy
MH  - Female
MH  - HSP70 Heat-Shock Proteins/genetics/*metabolism
MH  - Humans
MH  - Interleukin-18/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/genetics/*metabolism
EDAT- 2007/03/06 09:00
MHDA- 2007/07/07 09:00
CRDT- 2007/03/06 09:00
PHST- 2005/10/26 00:00 [received]
PHST- 2005/12/12 00:00 [revised]
PHST- 2005/12/14 00:00 [accepted]
PHST- 2007/03/06 09:00 [pubmed]
PHST- 2007/07/07 09:00 [medline]
PHST- 2007/03/06 09:00 [entrez]
AID - S0967-5868(06)00067-1 [pii]
AID - 10.1016/j.jocn.2005.12.022 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2007 May;14(5):435-41. doi: 10.1016/j.jocn.2005.12.022. Epub 
      2007 Mar 2.