PMID- 17338797
OWN - NLM
STAT- MEDLINE
DCOM- 20070326
LR  - 20070306
IS  - 1610-0387 (Electronic)
IS  - 1610-0379 (Linking)
VI  - 5
IP  - 3
DP  - 2007 Mar
TI  - Subacute cutaneous lupus erythematosus with bullae associated with porphyria 
      cutanea tarda.
PG  - 220-2
AB  - A 58-year-old patient presented with both annular and polycyclic as well as 
      vesicular lesions. Histology revealed an interface dermatitis with focal 
      hyperkeratosis and subepidermal blistering. Antinuclear antibodies were elevated 
      (1 : 1280) and autoantibodies against Ro-SS-A were found. Based on these findings 
      we made a diagnosis of subacute cutaneous lupus erythematosus (SCLE) with blister 
      formation. Additionally, we diagnosed porphyria cutanea tarda (PCT) triggered by 
      alcohol abuse. Treatment with systemic corticosteroids and low-dose 
      hydroxy-chloroquine led to rapid resolution of the skin changes. SCLE with 
      blister formation is a rare cause of bullous skin eruptions and has to be 
      distinguished from bullous autoimmune diseases as well as from bullous SLE. 
      Recognition of concomitant PCT, which may be associated with all forms of LE, is 
      especially important because of the therapeutic implications, since a reduced 
      dosage of antimalarials is required.
FAU - Peitsch, Wiebke K
AU  - Peitsch WK
AD  - Department of Dermatology, Mannheim University Clinic, Heidelberg University, 
      Mannheim, Germany. wiebke.peitsch@haut.ma.uni-heidelberg.de
FAU - Lorentz, Katharina
AU  - Lorentz K
FAU - Goebeler, Matthias
AU  - Goebeler M
FAU - Goerdt, Sergij
AU  - Goerdt S
LA  - eng
LA  - ger
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - J Dtsch Dermatol Ges
JT  - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German 
      Society of Dermatology : JDDG
JID - 101164708
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Drug Combinations)
RN  - 0 (Steroids)
SB  - IM
MH  - Alcoholism/*complications/diagnosis
MH  - Anti-Infective Agents, Local/therapeutic use
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Blister/*diagnosis/*etiology/prevention & control
MH  - Drug Combinations
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*complications/*diagnosis/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Porphyria Cutanea Tarda/*diagnosis/drug therapy/*etiology
MH  - Steroids/therapeutic use
MH  - Treatment Outcome
EDAT- 2007/03/07 09:00
MHDA- 2007/03/27 09:00
CRDT- 2007/03/07 09:00
PHST- 2007/03/07 09:00 [pubmed]
PHST- 2007/03/27 09:00 [medline]
PHST- 2007/03/07 09:00 [entrez]
AID - DDG06201 [pii]
AID - 10.1111/j.1610-0387.2007.06201.x [doi]
PST - ppublish
SO  - J Dtsch Dermatol Ges. 2007 Mar;5(3):220-2. doi: 10.1111/j.1610-0387.2007.06201.x.