PMID- 17339080
OWN - NLM
STAT- MEDLINE
DCOM- 20070622
LR  - 20181113
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 417
IP  - 1
DP  - 2007 Apr 24
TI  - Increased accumbens Cdk5 expression in rats after short-access to 
      self-administered cocaine, but not after long-access sessions.
PG  - 100-5
AB  - Upregulation of cyclin-dependent kinase 5 (Cdk5) after chronic cocaine 
      administration has led to speculation that Cdk5 plays an important role in drug 
      addiction. However, as Cdk5 involvement is implicated in a variety of neural 
      events, including neuronal development, synaptic plasticity and learning, a 
      specific role in drug abuse is yet to be determined. The present study utilized 
      cocaine self-administration and food-reinforced operant procedures to assess 
      possible relationships between cocaine intake, food-reinforced operant 
      responding, behavioral activity, and Cdk5 levels in the nucleus accumbens (NAcc), 
      ventral tegmental area (VTA), and prefrontal cortex (PFC) in rats. In Experiment 
      1, animals undergoing daily cocaine self-administration (1-h/30 days) or 
      food-reinforced operant sessions (20-min/30 days) showed significant 
      between-group differences in operant responding and behavioral activity, but no 
      significant differences in NAcc, VTA or PFC Cdk5 levels compared to a Handled 
      Control group. In Experiment 2, animals that had self-administered cocaine in 10 
      daily 1-h sessions (Short-Access Cocaine) showed significantly greater NAcc Cdk5 
      expression compared to an Unhandled Control group, and no evidence of 
      cocaine-induced behavioral sensitization. Animals given 4-h daily access to 
      cocaine over the same number of sessions (Long-Access Cocaine) showed 
      significantly enhanced cocaine-reinforced responding and locomotor activation by 
      the end of the sessions, but no significant differences in Cdk5 expression 
      compared to Control animals. These findings suggest that overexpression of Cdk5 
      may be a transient adaptation to cocaine experience that subsides with increased 
      cocaine exposure and does not correspond with measures of cocaine-induced 
      behavioral sensitization.
FAU - Seiwell, Andrew P
AU  - Seiwell AP
AD  - College of Pharmacy, Division of Pharmacology and Toxicology, The University of 
      Texas, 1 University Station A1915, Austin, TX 78712-0125, USA.
FAU - Reveron, Maria E
AU  - Reveron ME
FAU - Duvauchelle, Christine L
AU  - Duvauchelle CL
LA  - eng
GR  - R01 DA014640/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20070220
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - EC 2.7.11.1 (Cyclin-Dependent Kinase 5)
RN  - EC 2.7.11.22 (Cdk5 protein, rat)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Adaptation, Physiological/drug effects/physiology
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Cocaine/*pharmacology
MH  - Cocaine-Related Disorders/*enzymology/genetics/physiopathology
MH  - Conditioning, Operant/drug effects/physiology
MH  - Cyclin-Dependent Kinase 5/*drug effects/*metabolism
MH  - Dopamine Uptake Inhibitors/pharmacology
MH  - Drug Administration Schedule
MH  - Drug Tolerance/physiology
MH  - Enzyme Activation/drug effects/physiology
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Nucleus Accumbens/*drug effects/*enzymology/physiopathology
MH  - Prefrontal Cortex/drug effects/enzymology/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reward
MH  - Self Administration
MH  - Time Factors
MH  - Up-Regulation/drug effects/physiology
MH  - Ventral Tegmental Area/drug effects/enzymology/physiopathology
PMC - PMC1876973
MID - NIHMS22085
EDAT- 2007/03/07 09:00
MHDA- 2007/06/23 09:00
PMCR- 2008/04/24
CRDT- 2007/03/07 09:00
PHST- 2006/12/01 00:00 [received]
PHST- 2007/02/13 00:00 [revised]
PHST- 2007/02/13 00:00 [accepted]
PHST- 2007/03/07 09:00 [pubmed]
PHST- 2007/06/23 09:00 [medline]
PHST- 2007/03/07 09:00 [entrez]
PHST- 2008/04/24 00:00 [pmc-release]
AID - S0304-3940(07)00211-X [pii]
AID - 10.1016/j.neulet.2007.02.043 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Apr 24;417(1):100-5. doi: 10.1016/j.neulet.2007.02.043. Epub 
      2007 Feb 20.